Cain, Delver R., Van De Velde, Robert, and Shapiro, Stephen J.: Spironolactone inclusions in an aldosteronoma. Am. J. Clin. Pathol. 61: 412-416, 1974. Spironolactone cytoplasmic inclusions were found in an aldosteronoma but not in the adjacent zona glomerulosa of an adrenal gland that was removed because of aldosteronism. Their light and electron microscopic appearance was similar to that of pr...

accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. nadph oxidase has been recognized as a major source of oxidative stress in vasculature. however, the relation between nadph oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. the present study aimed to investigate the rele...

Prolonged treatment with the aldosterone antagonist spironolactone is well-established in the syndrome of hypertension with aldosterone excess and low plasma renin ("primary" hyperaldosteronism) and is usually effective in lowering the blood pressure and correcting the electrolyte abnormalities in cases with adrenocortical adenoma or micronodular hyperplasia (Brown et al., 1965, 1969, 1971b, 19...

• Objective: To assess the impact of interventions to increase the use of spironolactone in patients with congestive heart failure (CHF) due to ventricular systolic dysfunction. • Methods: Charts of patients admitted to the medicine department of a single hospital with a primary diagnosis of class IV CHF and left ventricular ejection fraction of 40% or less were randomly selected and reviewed. ...