The first joint Japanese Society of Toxicologic Pathology (JSTP) and National Toxicology Program (NTP) Satellite Symposium, entitled "Pathology Potpourri," was held on January 29(th) at Okura Frontier Hotel in Tsukuba, Ibaraki, Japan, in advance of the JSTP's 29(th) Annual Meeting. The goal of this Symposium was to present current diagnostic pathology or nomenclature issues to the toxicologic p...

a 52-year-old post-menopausal female was admitted to the emergency room due to acute onset of abdominal pain in the right lower quadrant. there was no history of trauma of the abdomen. contrast-enhanced multi-detector computed tomography (mdct) of the abdomen and pelvis revealed a massive right retroperitoneal hematoma and contrast extravasation from a right ovarian artery aneurysm. digital sub...

Spontaneous pneumothorax can be either primary due to the rupture of subpleural bleb or secondary due to underlying lung disease, usually bullous emphysema.1 Relatively little is known about the causative factors of spontaneous pneumothorax in Arab Countries.1 This is the first study and the primary step towards understanding the risk factors and causes of spontaneous pneumothorax in Syria.Syri...

Mutations in the p53 gene have been implicated to play an important role in the development of various human cancers. To evaluate the importance of p53 in lung cancer, a transgenic mouse model was established by utilizing the Clara cell secretory protein (CCSP) promoter to target the expression of a dominant-negative mutant form of p53 (dnp53) in the lung. In two transgenic CCSP-dnp53 founder l...

The effects of new antidiabetic drug Diabenol (9-beta-diethylaminoethyl-2,3-dihydroimidazo-(1,2-alpha)benzimidazol dihydrochloride) on life span and spontaneous tumor incidence in NMRI and transgenic HER-2/neu mice as well as on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats are studied. It is shown that treatment with the drug failed influence body weight gain dynamics, food and...

The biological properties of l,4-dimethyl-l,4-diphenyl-2-tetrazene (centrazene), a new anti-neoplastic compound which is not an alkylating agent, were described and compared with those of thioTEPA. Short-term studies demonstrated that both centrazene and thioTEPA inhibited the growth of 72j mammary adenocarcinoma growing in C3H mice. ThioTEPA produced concurrent bone marrow damage, and its effe...

In a model of metastasis, the fate of radioactively labeled cells cultured from spontaneous tumors was studied by i.v. injection into animals syngeneic with the tumor. Double isotope labeling of the cells produced a 14C/3H ratio that was used to identify putatively undamaged cells within the tissues. It was found that within 5 min of injection the cells concentrated almost exclusively in the lu...

BACKGROUND Although well-acknowledged in vivo, spontaneous death of cancer cells in vitro is less widely appreciated. MATERIALS AND METHODS Colony formation was studied in untreated control plates of standard clonogenic assays and measurements of actual and potential doubling times performed in asynchronous cultures of human cancer cells lines. Western blotting of lung large cell carcinoma, C...