نتایج جستجو برای: sporadic prostate cancer
تعداد نتایج: 951267 فیلتر نتایج به سال:
Background: MiRNAs are one of the most important genetic regulators that regulate more than 50 percent of the human genome. MiR-124-a-3 is a tumor suppressor miRNA which its expression dramatically reduced in prostate cancer tumor cells. Since miRNA binding to the transcript of target genes by seed sequence, any mutations and changes in this region could be effective on its performance and iden...
Background and Aim: Prostate cancer is one of the most prevalent type of cancer and the second cause of death among American men. Its prevalence has a direct relationship with increasing age. The present study was carried out to determine the level of prostate specific antigen (PSA) in Birjandi males aged between 40 and 80 years. Material and Methods: In this prospective study, out of 62...
BACKGROUND The precise genes involved in conferring prostate cancer risk in sporadic and familial cases are not fully known. OBJECTIVES To evaluate the genetic profile within several candidate genes of unselected prostate cancer cases and to correlate this profile with disease parameters. METHODS Jewish Israeli prostate cancer patients (n = 224) were genotyped for polymorphisms within candi...
Loss of heterozygosity (LOH) on chromosome arm 16q is one of the most consistent genetic alterations in sporadic prostate cancer and may be involved in cancer development through inactivation of tumor suppressor genes. A candidate tumor suppressor gene on this chromosome arm, CDH1 at 16q22.1, is dysregulated in prostate cancer. However, no specific deletion map has been constructed from prostat...
BACKGROUND A single nucleotide variation within catechol-o-methyl transferase (COMT) gene may alter the COMT enzyme activity level. Polymorphism of Val158Met in the COMT gene has been related to malignancy. In this regard, a study was carried out to find a possible association between the COMT gene polymorphism in patients with sporadic prostate cancer (PCa) and benign prostatic hyperplasia (BP...
Background: In recent years the use of Prostate Specific Antigen test (PSA) has reduced the mortality rate of prostate cancer. Certain factors by affecting the levels of PSA, decrease or increase prostate cancer detection. Some studies suggest the effect of body weight and Body Mass Index (BMI) on PSA, while some others are contrary to the opinion mentioned.. Hence, in this study we ex...
Background: Prostate specific antigen (PSA) is an important biomarker to monitor patients after treated with radiation therapy (RT). The aim of this study is to evaluate the relationship between the PSA data and prostate cancer recurrence using the joint modeling. Methods: This historical cohort study was performed on 422 prostate cancer patients. Inclusion criteria included: patients with loc...
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