Pulmonary administration of protein and peptide drugs using inhaled dry powder particles is an interesting alternative to parenteral delivery. The stabilisation of these molecules is essential to the maintenance of biological activity in such inhalation formulations. Here salmon calcitonin (sCT) was co-spray dried with linear or branched PEG (L-PEG and B-PEG) and PVP in order to formulate aeros...

The aim of this study was to design, develop, and optimize respirable tacrolimus microparticles and nanoparticles and multifunctional tacrolimus lung surfactant mimic particles for targeted dry powder inhalation delivery as a pulmonary nanomedicine. Particles were rationally designed and produced at different pump rates by advanced spray-drying particle engineering design from organic solution ...

D. Niblett, S. C. Porter, I. Gabbott, G. Reynolds, T. Morgan, K. Karan, J. Greenamoyer, R. Hach University of Manchester, Ashland Specialty Ingredients, AstraZeneca Purpose Aqueous film coating still remains a complex process in which the process parameters selected can have a major impact on ultimate product quality. In this study, a wide range of processing parameters was performed in order t...

Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation solid dosage forms requires the drying PECs, which may affect their physicochemical and biopharmaceutical properties. aim this study was investigate effect spraydrying on properties ibuprofen-loaded chitosan/xanthan ...

Response surface methodology was applied for optimization of the sour cherry Marasca juice spray drying process with 20, 30 and 40% of carriers maltodextrin with dextrose equivalent (DE) value of 4-7 and 13-17 and gum arabic, at three drying temperatures: 150, 175 and 200 °C. Increase in carrier mass per volume ratio resulted in lower moisture content and powder hygroscopicity, higher bulk dens...

Particles of fungicide encapsulated in lecithin and β-glucans were obtained in order to improve the action of the product against Botrytis cinerea. For this purpose, supercritical drying processes such as PGSS and SAS were performed and compared to conventional spray-drying. It was concluded that SAS is not a suitable process for these products. However, particles were well dried by any of the ...

Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. Microspheres are characteristically free flowing po...

Spray-drying of clear precursor solution containing inorganic-organic hybrid species and EO(n)PO(m)EO(n) triblock copolymer at low temperature, followed by treatment in acetone to remove the triblock copolymer, afforded spherical particles of aluminium organophosphonate (AOP) with uniform mesopores.