Selective serotonin reuptake inhibitors (SSRIs) are associated with significant sexual side effects. By definition, all SSRIs increase overall serotonin (5HT) by binding to serotonin autoreceptors (5HT(IA)); however, each SSRI has a unique portfolio of secondary binding properties to other neurotransmitters such as norepinephrine (NE). As 5HT(IA) receptors mediate NE neurotransmission, SSRIs th...

Amaç: Bruksizm; dişlerin kontrolsüz bir şekilde sıkılması veya gıcırdatılması ile karakterize tekrarlayan çiğneme kas aktiviteleridir. Selektif Serotonin Gerialım İnhibitörü grubu antidepresanların (SSRI-AD) bruksizme yol açtığına yönelik raporlar vardır. Bu çalışmanın amacı, SSRI-AD kullanan ve bruksizmi olan hastaların ilaç kesilerek bruksizm tablosunun düzelip düzelmeyeceğini araştırmaktır. ...

Patients with frontotemporal lobar degeneration (FTLD) present a profound personality change, social misconduct, overeating, and stereotyped behavior. We examined the hypothesis that many of the behavioral symptoms of FTLD will respond to selective serotonin reuptake inhibitors (SSRIs). Sixteen FTLD patients were treated with an SSRI (fluvoxamine maleate) in an open 12-week trial. Treatment res...

SSRI are the widely prescribed first line drugs for depression and as depression very commonly presents with insomnia SSRI are good at improving the sleep problems also. But though rare the occurrence of sleep related side effects like bruxism,it may cause significant distress and cause of nonadherence which easily may be overlooked. In this case we report a case of Paroxetine induced bruxism a...

BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are typically used as antidepressants. Clinically significant SSRI-induced thyroid dysfunction is rare. CASE We report a case of hyperthyroidism induced by fluoxetine in a female patient with major depressive disorder. Her thyroid profiles indicated hyperthyroidism after a 10-week treatment with fluoxetine and were restored after disc...

The authors review the literature pertaining to selective serotonin reuptake inhibitor (SSRI)-induced apathy syndrome. A literature search of Medline and International Pharmaceutical Abstracts from 1970 to the present was performed for relevant articles. Twelve relevant case reports and one open-label treatment trial were identified. An amotivational, or apathy, syndrome has been reported in a ...

Review scope Included studies compared any SSRI (e.g., fluvoxamine, fluoxetine, sertraline, citalopram, or paroxetine), at any dose and for any duration or reason, with placebo or usual care in stroke survivors within 12 months of stroke or a reported mean time < 12 months since stroke (sudden-onset focal neurologic disturbance, assumed to be vascular in origin, and lasting > 24 h), and reporte...