OBJECTIVES The goal of this work was to determine whether rheolytic thrombectomy (RT) as an adjunct to primary percutaneous coronary intervention (PCI) reduces infarction size and improves myocardial perfusion during treatment of ST-segment elevation myocardial infarction (STEMI). BACKGROUND Primary PCI for STEMI achieves brisk epicardial flow in most patients, but myocardial perfusion often ...

More than 30 years ago, thrombotic occlusion of a coronary artery was identified as the pathophysiological mechanism causing myocardial infarction (1). Mechanical and/or thrombolytic reperfusion has subsequently become the standard of care for patients with ST-segment elevation myocardial infarction (STEMI). However, reperfusion of the epicardial coronary artery does not guarantee reperfusion a...

Cocaine-associated coronary artery disease and ST-segment elevation myocardial infarction (STEMI) have been well described in the literature. However, very few cases of cocaine-induced multivessel reported. We report a rare case cocaine-associated triple vessel 41-year-old male patient. The patient underwent urgent catheterization that revealed occlusion his proximal left anterior descending (L...

Acute coronary syndromes are a major public health problem and the leading cause of death in the western world. Acute coronary syndromes consist of unstable angina pectoris, non-ST-segment-elevation myocardial infarction, and ST-segment-elevation myocardial infarction. These diseases represent a continuum of increasing severity and are pathophysiologically linked to intracoronary thrombus forma...

Vijayaraghavan et al. have investigated the interpretation of the initial 12-lead electrocardiogram (ECG) in acute coronary syndrome (ACS) patients, focusing on the patient with potential ST segment elevation myocardial infarction (STEMI). The authors emphasize the importance of accurate ECG interpretation by the acute care physician (i.e. emergency physician, internist, and cardiologist). The ...

INTRODUCTION There is a paucity of data on acute myocardial infarction (AMI) in young Asian women and of comparative data among various ethnic groups with respect to risk factor profile and clinical outcomes. We present a comprehensive overview of the clinical characteristics of young Asian women with AMI and a comparative analysis among Chinese, Malay and Indian women in a multi-ethnic Asian c...

BACKGROUND For patients with ST-segment elevation myocardial infarction transferred for primary percutaneous coronary intervention, guidelines have called for device activation within 90 minutes of initial presentation. Fewer than 20% of transferred patients are treated in such a timely fashion. We examine the association between transfer drive times and door-to-device (D2D) times in a network ...

ST segment elevation myocardial infarction (STEMI) is one of major causes of morbidity and mortality in Asian and other patients worldwide. 1-3 There is substantial and important research dedicated to improving clinical outcomes for patients after STEMI. 1-8 Primary percutaneous coronary intervention (PCI) was shown to be more effective than thrombolytic therapy for the treatment of STEMI in ce...

Cardiac Magnetic Resonance: Role in Infarct Characterization Cardiac magnetic resonance (CMR) imaging in survivors of acute ST-segment–elevation myocardial infarction (STEMI) provides accurate and precise measurements of left ventricular dimensions, and infarct pathologies are uniquely characterized. Acute coronary artery occlusion initiates a wavefront phenomenon of ischemia commencing from th...

Blood transcriptome reflects the status of diseases, and characteristic molecular signature provides a novel window on gene expression preceding acute coronary events. We aim to determine blood transcriptome-based molecular signature of acute coronary syndrome (ACS), and to identify novel serum biomarkers for early stage ST-segment-elevation myocardial infarction (STEMI). We obtained peripheral...