Introduction. Pulmonary embolism (PE) is one of the leading causes death even in hospitalized patients. The standard treatment results are disappointing. Since 2004, we have tested a new method for hemodynamically insignificant PE (own patent RU2224525C1) by using unfractionated heparin (UFH) ultrasound inhalations with nebulizer, since 2014 – combination apixaban. Aim. To improve PE. Materials...

The relative importance of antithrombin and anti-factor Xa activities of heparin fractions required to achieve optimal antithrombotic effects is unknown. To study this. we measured the effects of standard heparin. an octasaccharide heparin fraction (anti-factor Xa activity only). and dermatan sulfate (antithrombin activity only) on the prevention of thrombosis and related this to their anticoag...

Thrombelastography (TEG) correlates with postoperative chest drain output in patients undergoing cardiopulmonary bypass (CPB). In vitro incubation with heparinase allows TEG monitoring during CPB, despite heparin anticoagulation. Hypothermia impairs coagulation, but these effects cannot be assessed by standard coagulation tests performed at 37 degrees C. The aim of this study was to assess the ...

Heparin-induced thrombocytopenia (HIT) is a problem of growing significance and concern, affecting an estimated 1-3% of patients among those receiving an estimated 10 million heparin exposures annually in the United States. The prevalence of heparin antibodies has been reported as at least 12.7% in the general cardiac surgery population before surgery and 42% following surgery. Various manageme...

OBJECTIVE To determine reheparinisation requirements following protamine neutralisation after the discontinuation of cardiopulmonary bypass in a group of patients receiving "low dose" aprotinin compared with a control group. DESIGN Randomised, placebo controlled study. SETTING Regional cardiothoracic unit within a district general hospital. PATIENTS 20 patients were consecutively allocate...

Background: Coronary angiography consists of the selective injection of contrast agents in coronary arteries. Optimal strategy for heparin administration during coronary angiography has yet to be determined. We assessed the effect of heparin administration during coronary angiography on vascular, hemorrhagic, and ischemic complications.Methods: Five hundred candiates for diagnostic coronary ang...

Sulfated polysaccharides constitute a large and complex group of macromolecules which possess a wide range of important biological properties. Many of them hold promise as new therapeutics, but determination of their blood levels during pharmacokinetic studies can be challenging. Heparin Red, a commercial mix-and-read fluorescence assay, has recently emerged as a tool in clinical drug developme...

Thrombin stimulates and heparin and heparan sulfate inhibit mesangial cell proliferation. In addition, heparin has been shown to inhibit thrombin-stimulated smooth muscle cell proliferation. The anticoagulant action of heparin is mediated by antithrombin Ill. This study investigated whether heparin’s antiproliferative action is also mediated by antithrombin Ill. To this end, the effect of antit...