OBJECTIVE We conducted this study to report the efficacy of local application of vancomycin powder in the setting of surgical site infection (SSI) of posterior lumbar surgical procedures and to figure out risk factors of SSIs. METHODS From February 2013 to December 2013, SSI rates following 275 posterior lumbar surgeries of which intrawound vancomycin powder was used in combination with intra...

Prosthetic joint infection (PJI) is a devastating complication in total knee arthroplasty (TKA) and third most common cause of revision of TKA with significant morbidity and surgical challenges. Treatment options include non-operative measures with long term antibiotic suppression, debridement and implant retention (DAIR), one- or two-stage revision arthroplasty, arthrodesis and amputation. Imp...

IT can be said with certainty that, in most general hospitals today, staphylococcal infection is the major bacteriological problem. The introduction of penicillin in 1941 proved so successful against this type of infection that many were lulled into a false sense of security. It has become increasingly apparent over the last ten years that the adaptability of the staphylococcus has been underes...

  Background : The development of microbial resistance to the existing anti-microbial agents has become a real challenge and a serious problem facing patients suffering from skin infections. Seeds of Nigella sativa have been used for a long time in folk medicine for the treatment of skin infections. Production of new potent agents is urgently needed, especially for hospitals and health care cen...

Worldwide, cefazolin is one of the most commonly used antibiotics, as revealed in a recent article this Journal, 1 Thamlikitkul V. Rattanaumpawan P. Sirijatuphat R. Wangchinda W. Integrated one-day surveillance antimicrobial use, consumption, resistance, healthcare-associated infection, and resistance burden among hospitalized patients Thailand. J Infect. Jul 2020; 81: 98-106 Abstract Full Text...

IgA-dominant acute postinfectious glomerulonephritis (APIGN) is an increasingly recognized morphologic variant of APIGN, particularly in the elderly. In contrast to classic APIGN, in which there is typically glomerular deposition of IgG and C3 or C3 only, IgA is the sole or dominant immunoglobulin in IgA-dominant APIGN. Because the vast majority of reported cases occur in association with staph...

A reduction in pulmonary anti-bacterial activity due to a preceding viral illness has been suggested as the mechanism responsible for some meningococcal infections of the lung. We investigated this proposed pathogenesis by infecting mice with airborne encephalomyocarditis virus (EMC) and then challenging them 1, 4, and 7 days later with aerosols of Neisseria meningitidis. Meningococcal clearanc...

Staphylococcus aureus is responsible for a wide range of infections, including soft tissue infections and potentially fatal bacteremias. The primary niche for S. aureus in humans is the nares, and nasal carriage is a documented risk factor for staphylococcal infection. Previous studies with rodent models of nasal colonization have implicated capsule and teichoic acid as staphylococcal surface f...

BACKGROUND Hand hygiene is generally considered to be the most important measure that can be applied to prevent the spread of healthcare-associated infection (HAI). Continuous emphasis on this intervention has lead to the widespread opinion that HAI rates can be greatly reduced by increased hand hygiene compliance alone. However, this assumes that the effectiveness of hand hygiene is not constr...

The studies of Phemister1 in 1924 and the more recent investigations of Curtiss and Klein2 have clarified some of the mechanisms of destruction of cartilage by purulent exudate. Other aspects of joint infections have not been so well studied. Our observations in the rabbit explore the pathophysiology of pyarthrosis and the role of some host defense factors in staphylococcal joint infection. The...