background: the electrical dose selected for electroconvulsive therapy (ect) must have an acceptable efficacy and no or minimal cognitive side-effects. we evaluated the clinical efficacy and cognitive side-effects of ect in relation to the stimulus dose administered.   method: this study assessed 71 depressed patients who were treated with bilateral ect. for evaluation of depressive and cogniti...

background: changes in body composition may be used for monitoring progression/ regression of a disease. prompt γ-rays in vivo neutron activation analysis (ivnaa) has been widely used for the measurement of body composition in recent years. objective: in this paper, we tried to improve the safety of ivnaa operator. methods: the most important factor for reducing the operator receiving dose is t...

lent, considered by many to be one of the best sailing areas in the country, provided an opportunity not to be missed. Although my initial trip out was in a yacht, most of my early experience was in dinghies less expensive to buy and to repair if damaged. The first dinghy I shared was with three other equally inexperienced friends. We bought a 14 foot fibre glass family dinghy through Exchange ...

When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin discriminates among its many potential cargo molec...

Abstract Background Afatinib has shown favorable response rates (RRs) and longer progression free survival (PFS) in lung cancer patients harboring EGFR mutations compared with standard platinum-based chemotherapy. However, serious adverse drug reactions (ADRs) limit the clinical application of afatinib. Methods We designed a retrospective study, enrolling all metastatic adenocarcinoma who were ...

background: surgical site infection is known as a common complication after cardiac surgery, and cefazolin is the best prophylactic antibiotic to prevent this complication. the goal of this study was to evaluate the effect of continuous and intermittent cefazolin for the prevention of superficial surgical site infection following off-pump coronary artery bypass (opcab). methods: this prospectiv...

OBJECTIVE We investigated the efficacy and tolerability of ziprasidone combined with divalproex to determine the relationship between the initial dose of ziprasidone and the treatment effect among Korean patients with acute bipolar manic or mixed disorders. METHODS This study was a 6-week, open-label, prospective investigation of Korean patients with an acute manic or mixed episode of bipolar...

A phase II trial in metastatic breast cancer (MBC) (NO16853) failed to show noninferiority (progression-free survival, PFS) of capecitabine 825 mg/m(2) plus docetaxel 75 mg/m(2) to the registered capecitabine dose of 1,250 mg/m(2) plus docetaxel 75 mg/m(2). We developed a modeling framework based on NO16853 and the pivotal phase III MBC study, SO14999, to characterize the link between capecitab...

DOI: 10.1002/advs.201700872 Who would have believed it? When we launched Advanced Science in December 2014, everyone in the editorial team agreed that it was a fantastic idea to create a forum for top science, open to read, download, and share with everyone, but the development that this young journal has undergone during the last three years has stunned even the most optimistic among us. Figur...

Background The optimal stimulation protocol for poor responder patients is a therapeutic challenge. GnRH antagonist protocol has been proposed as a potentially proper option for poor responders. Nevertheless, there is no significant difference in terms of clinical pregnancy and cancellation rates be tween the GnRH antagonist and agonist cycles. Therefore, this subset of patients might be the be...