Dept of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, The Netherlands; Research Center and Dept of Medicine; Montreal Heart Institute and Université de Montréal, Montreal, Canada; Chang-Gung Memorial Hospital and ChangGung University, Taoyuan, Taiwan, Republic of China; Nyken BV, Groningen, The Netherlands; Ankara University Biotechnology Institute, Ankara...

The promise of stem cells for therapy of a variety of disease conditions is one of the most heavily marketed commodities of modern biotechnology. Interest in this prospect has opened up and destabilized a large area of developmental biology, challenging some of its major tenets, and becoming a source of controversy. Much of the disagreement arises from apparently simple conflicts of findings, w...

Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In ad...

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bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. recently, various stem cells, including embryonic stem cells (escs), bone marrow-derived mesenchymal stem cells (bm-mscs), umbilical cord blood-derived mesenchymal stem cells (ucb-mscs), adipose tissue-derived stem cells (adscs), muscle-derived stem cell...

articular cartilage, the load-bearing tissue of the joint, has limited repair and regeneration ability. the scarcity of treatment modalities for large chondral defects has motivated researchers to engineer cartilage tissue constructs that can meet the functional demands of this tissue in vivo. cartilage tissue engineering requires 3 components: cells, scaffold, and environment. owning to their ...

parkinson’s disease (pd) is the second most common neurodegenerative brain disorder which is around 1.5 times more common in men than in women. currently, drug medications, surgery, and lifestyle changes are common approaches to pd, while all of them focused on reducing the symptoms. therefore, regenerative medicine based on stem cell (sc) therapies has raised a promising hope. various types of...

objective(s): in the past few decades, variety of foetal, embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases. cellular characteristics and functional plasticity of globose basal stem cells (gbcs) residing in the olfactory epithelium of rat olfactory mucosa have not been studied in the past by the ...

introduction: allogeneic hematopoietic stem cell transplantation is a potentially curative treatment modality for hematological malignancies. we evaluated the outcome of patients suffering from hematological malignancies, including acute leukemias, chronic myeloid leukemia and myelodysplastic syndrome after allogeneic transplantation. methods: all patients having hematological malignancies with...

background: antibiotic prophylaxis is usually used in allogenic stem cell transplantation, but its use in autologous stem cell transplantation (asct) is controversial. we evaluated the efficacy of ciprofloxacin prophylaxis in asct. materials and methods: to identify the efficacy of ciprofloxacin on the incidence of neutropenic fever and its complications, 72 patients had been admitted to talegh...