BACKGROUND AND PURPOSE Cerebral vascular reactivity assessment is typically performed with 2 perfusion measurements before and after a vasodilatory challenge. The aim of this study was to assess the time course of the vasodilatory effect in the brain-feeding arteries after a challenge with acetazolamide in patients with a stenosis of the internal carotid artery (ICA). METHODS Twenty-one patie...

Histological images from the longitudinal section of four diseased coronary arteries were used, for the first time, to study the pulsatile blood flow distribution within the lumen of the arteries bymeans of computational fluid dynamics (CFD). Results indicate a strong dependence of the hemodynamics on themorphology of atherosclerotic lesion. Distinctive flow patterns appear in different stenose...

BACKGROUND Blood flow analysis of the human right coronary artery (RCA) has been carried out to investigate the effects of serial stenosis on coronary hemodynamics. A 3-D model of a serial stenosed RCA was reconstructed based on multislice computerized tomography images. METHODS A velocity waveform in the proximal RCA and a pressure waveform in the distal RCA of a patient with a severe stenos...

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BACKGROUND AND PURPOSE Carotid ultrasonography is being increasingly performed as the sole investigation to assess internal carotid artery (ICA) stenosis. A potential source of error in using ultrasound peak systolic velocity (PSV) measurements is that the redistribution of blood flow due to severe stenosis in a contralateral carotid artery may lead to artificially elevated values. METHODS Ul...

protective value are rather contradictory. Chronic alcohol consumption reduces the absolute level of the anti-atherogenic LpAI fraction of HDL while the LpAI:LpAII ratio improves the level.' Despite this observation, the risk-reducing effect of alcohol has been demonstrated in angiographically proven coronary artery disease.' It has also been suggested that alcohol has an important effect on th...

Angiographically determined changes in segmental wall motion (SWM) and ejection fraction (EF) are sensitive indices of left ventricular (LV) function. To compare the effects of exercise on LV function, first pass radionuclide angiocardiography was used before and during maximal upright bicycle stress in patients with nonsignificantly stenosed coronary arteries, and in those with greater than 75...