Transforaminal epidural steroid injections are provided frequently for patients with lumbar radiculopathy, having demonstrated efficacy and safety. We present a patient who developed methicillin-resistant Staphylococcus aureus epidural abscess 11 days after a transforaminal epidural steroid injection. The abscess required surgical intervention and intravenous vancomycin. Fortunately, the patien...

We describe a case of severed and steroid-resistant limbal vernal keratoconjunctivitis (VKC) with deficient stem cells, papillary hypertrophies, its pattern management topical eye drops tacrolimus (TAC) interferon alpha-2b (IFN- ∝ 2b) . The present study is report and review the literature. A woman aged 20 years complaint decreased vision, ocular surface burning, photophobia in both e...

Steroid-resistant nephrotic syndrome (SRNS) is a clinically and genetically heterogeneous disorder caused by either genetic or immunological factors their combination. Approximately 30-40% of patients with SRNS make fast progression to end-stage renal disease (ESRD). represents the second leading cause ESRD in individuals under age 25 years worldwide. Patients typically exhibit focal segmental ...

AIM The aim of this study was to determine the long-term results of children followed up with a diagnosis of nephrotic syndrome in a single center. MATERIALS AND METHOD The medical data of 33 patients aged between 6 months and 10 years who were diagnosed with idiopathic nephrotic syndrome in our center between January 2000 and December 2012 and followed up for a period of 2-12 years were revi...

A 76-year-old woman with rheumatoid arthritis who had been taking methotrexate (MTX) for 9 months was admitted because of acute respiratory failure. A chest radiograph revealed diffuse ground-glass attenuation. MTX-induced interstitial pneumonia (IP) was strongly suspected. Her respiratory failure worsened in spite of steroid pulse therapy. Intravenous administration of ulinastatin, however, dr...

IDENTIFICATION OF A POTENTIAL TUMOR DIFFERENTIATION FACTOR (TDF) RECEPTOR FROM STEROID-RESPONSIVE AND STEROID-RESISTANT BREAST CANCER CELLS Izabela Sokolowska, Alisa G. Woods, Mary Ann Gawinowicz, Urmi Roy and Costel C. Darie From Department of Chemistry & Biomolecular Science, Biochemistry & Proteomics Group, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699-5810 and Protein Core Faci...

Editorial Implication for health policy/practice/research/medical education: Recent advances in molecular genetics have helped in unraveling the genetic component of idiopathic nephrotic syndrome in children. Similar advances in understanding the environmental triggers and immune defects will help better understand the pathogenesis of the disease. It is hoped that the above advancements will ul...

Background: Nephrotic syndrome (NS) is a common disease in children with many consequences for their health, particularly when the severe, accompanied by frequent recurrences, and must be treated high-dose, long-term corticosteroids. Objectives: We aimed to determine effect of birth weight on complete response corticosteroids NS. Methods: Two hundred ninety-two NS aged 1 - 18 years were include...

schimke immuno-osseous dysplasia is a rare autosomal recessive multisystem disorder characterized by steroid-resistant nephrotic syndrome, immunodeficiency, and spondyloepiphy-seal dysplasia. mutations in swi/snf2 related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 (smarcal1) gene are responsible for the disease. the present report describes, for the first tim...

Abstract Background Nephrotic syndrome is one of the most common chronic kidney diseases in children. Steroid sensitive type constitutes about 90% and steroid resistant 10% total cases. Objectives These national adapted guidelines aim to frame evidence-based recommendations adopted or from IPNA 2020, KDIGO 2021, Japanese 2014 for diagnosis, evaluation, management follow-up nephrotic children (S...