This paper discusses the effective length factor of columns in Khorjini frames. In order to find this factor, a proper approximated method is proposed. In addition, accurate analysis is performed and the results are compared with those from the proposed technique. The comparison demonstrates the accuracy of presented FORMULATIONS. The proposed method is similar to Julian and Lawrences, which is...

A generalised method for the identification of the parameters which describe the dynamic properties of media between coupled substructures using measured FRFs is presented in this paper. The effort is mainly focused on the development of this generalised method and the improvement of its constituent algorithms. The method presented here is more general and more practical in some aspects when co...

Matrix Stiffness Extracellular matrix stiffness-sensing studies are typically carried out using cells that have acquired “mechanical memory” through progressive passaging in rigid mechanical environments, e.g., tissue culture plastic (TCP). This confounds the mechanistic experiments investigate stiffness-driven mechanosensing programs. In article 2101216, Jess G. Snedeker and co-workers report ...

Cancer cell invasion from primary tumors is mediated by a complex interplay between cellular adhesions, actomyosin-driven contractility, and the physical characteristics of the extracellular matrix (ECM). Here, we incorporate a mechanochemical free-energy-based approach to elucidate how the two-way feedback loop between cell contractility (induced by the activity of chemomechanical interactions...

Increased aortic stiffness is an acknowledged predictor and cause of cardiovascular disease. The sources and mechanisms of vascular stiffness are not well understood, although the extracellular matrix (ECM) has been assumed to be a major component. We tested here the hypothesis that the focal adhesions (FAs) connecting the cortical cytoskeleton of vascular smooth muscle cells (VSMCs) to the mat...

In this paper, a simplified, economical and highly accurate method for large deformation, post-buckling, analyses of frame-type structures is presented. Using the concepts of polar-decomposition of deformation, an explicit expression for the tangent stiffness matrix of a member/element of the frame, that accounts for the nonlinear bending-stretching coupling, is derived in closed form, at any p...

We propose a fast stiffness matrix calculation technique for nonlinear finite element method (FEM). Nonlinear stiffness matrices are constructed usingGreen-Lagrange strains, which are derived from infinitesimal strains by adding the nonlinear terms discarded from small deformations. We implemented a linear and a nonlinear finite element method with the same material properties to examine the di...

Accuracy of the quarter-point and transition elements is investigated on oneand two-dimensional problems with inverse square-root singularity. It is demonstrated that most coefficients of the stiffness matrix of the quarter-point element are unbounded. However, numerical integration produces finite values of these coefficients. Influence of several parameters on the error in determining the str...