The biomechanical properties of the extracellular matrix (ECM) play an important role in cell migration, gene expression, and differentiation. Biomechanics measurements of ECM are usually performed on cryotomed tissue sections. However, studies on cell/matrix interplay are impossible to perform due to disruptions in cell viability and tissue architecture from freeze-thaw cycling. We developed a...

Here, we present the in-plane energy absorption characteristics of modified re-entrant auxetic honeycombs realized via fused filament fabrication in conjunction with parametric analysis and geometry optimization. The influence interaction effects geometrical parameters such as strut-length ratio joint-angles on stiffness, strength were evaluated. Subsequently, Finite Element results obtained us...

Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cultures that more closely resemble tissue has proven challenging, because perturbations that change...

The fibril reinforced poroelastic models have been found successful in describing some mechanical behaviors of articular cartilage in unconfined compression that were not understood previously, including the strong and nonlinear transient response, the strain-magnitude and strain-rate dependent cartilage stiffness and the depth-varying stresses and strains. It has been demonstrated that a bette...

Starting from the definition of a stiffness matrix, the authors present a new formulation of the Cartesian stiffness matrix of parallel mechanisms. The proposed formulation is more general than any other stiffness matrix found in the literature since it can take into account the stiffness of the passive joints, it can consider additional compliances in the joints or in the links and it remains ...

importance of covalent bonded two-dimensional monolayer nanostructures and also hydrocarbons is undeniably responsible for creation of new fascinating materials like polyphenylene polymer, a hydrocarbon super honeycomb network, so-called porous graphene. the mechanical properties of porous graphene such as its young’s modulus, poisson’s ratio and the bulk modulus as the determinative properties...

In this paper, an exact stiffness matrix and fixed-end load vector for nonprismatic beams having parabolic varying depth are derived. The principle of strain energy is used in the derivation matrix. effect both shear deformation coupling between axial force bending moment considered elements under uniformly distributed or concentrated loads also correctness derived matrices verified by numerica...

Recently, the warm mixing modified ultrathin abrasive layer has been paid great attention due to green energy-saving strength. In regard its durability, study of fatigue behavior SMC asphalt mixture was carried out under strain controlling mode. The relationship among all characteristic parameters (bending stiffness modulus, normalized times, and products phase angle) stress cycle times showed ...