Conjugates consisting of stigmasterol and L-phenylalanine, interconnected through short-chained dicarboxylic acyls by ester and amide bonds, respectively, were synthesized as potential low molecular weight/mass organic gelators (LMWGs/LMMGs). Their physico-chemical properties were subjected to investigation, especially their ability to form gels reversibly based on changes of the environmental ...

Krimpsiekte (the syndrome associated with chronic cardiac glycoside poisoning) was purportedly induced by Ornithlogalum toxicarium in the Karas mountains area of Keetmanshoop, Namibia. This chinkerinchee species was previously linked to a condition known as 'kwylbek' krimpsiekte in small stock in the Beaufort West district of the Western Cape Province, South Africa. In a dosing trial, respirato...

Certain glycolipid Ags for Valpha14i NKT cells can direct the overall cytokine balance of the immune response. Th2-biasing OCH has a lower TCR avidity than the most potent agonist known, alpha-galactosylceramide. Although the CD1d-exposed portions of OCH and alpha-galactosylceramide are identical, structural analysis indicates that there are subtle CD1d conformational differences due to differe...

Polyfunctionalized stigmasterol derivatives, (22S,23S)-22,23-dihydroxystigmast-4-en-3-one (compound 1) and (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (compound 2), inhibit herpes simplex virus type 1 (HSV-1) replication and spreading in human epithelial cells derived from ocular tissues. Both compounds reduce the incidence and severity of lesions in a murine model of herpetic stroma...

Capillary electrochromatographic (CEC) separations of plant sterols and related esters were evaluated under various conditions. Stationary phases included octadecylsilica (C18) and triacontylsilica (C30). Mobile phases comprised acetonitrile, tetrahydrofuran, and tris(hydroxymethyl) aminomethane buffers in aqueous or non-aqueous systems. Apart from notable differences in component resolution, b...

Abstract This paper presents a simple and rapid approach to the quantification of various glycosides using high-performance thin-layer chromatography (HPTLC). Different classes glycosides, represented by genistin ononin (both monosaccharidic O-glycosides), rutin (a disaccharidic O-glycoside) luteolin-6-C-glucoside C-glycoside), were successfully separated mixture ethyl acetate‒methanol‒glacial ...

Many disaccharides are usefu1 as lowcariogenic sweet rnaterials or potent bifidus factors, The syntheses of such oligosaccharides have been studied extensively using enzymatic transglycosylation reactions.i "'3) On the other hand, the condensation activity of glycosidases has not been used on a practical level for the synthesis of disaccharides, because the equilibrium of monoand disaccharides ...

A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine and codonopsinine using appropriate Grignard reagents. The hence obtained molecules have been tested against various commercially available glycosidases and found to act as moderate to good inhibitors.

Glycoside phosphorylases hold great potential as catalysts for the synthesis of valuable sugars, glycosides, and glycans or development energy-efficient microbial cell factories. However, number available phosphorylase specificities is rather limited. Here, we show that it possible to establish significant activity in GH3 glycoside hydrolases from Pseudomonas aeruginosa Bacillus subtilis. Singl...

Abstract Two unnatural regioisomeric glycosylated Gilvocarcin analogues were proposed as model compounds to study the origin behind biosynthetic development of Gilvocarcins, a class bioactive C ‐aryl glycoside natural products. More specifically, origins O ‐ ‐glycoside migration in evolution biosynthesis for these classes Angucycline antibiotic For stability reasons 5a‐carbasugar motif was used...