VER nearly half a century numerous workers have considered covariances and/or correlations between genotypic values of relatives and have related these population parameters to more basic parameters descriptive of the Mendelian mechanism of inheritance for diploids and the modes of gene action. FISHER (1918) considered random mating populations and developed formulae for the correlations betwee...

Introduction Reducing fracture risk is an important clinical objective given the mortality, disability, and cost associated with fragility fractures. Identifying the factors that define bone mass and bone quality is fundamental to understanding bone fragility. Although peak bone mass is largely genetically determined (Smith et al., 1973), the manner by which biomechanically-relevant geometric p...

Records of five inbred lines at the Livestock and Range Research Laboratory were used to evaluate effects of inbreeding and heterozygosity on preweaning traits. Members of each line were descendants of a single founder Hereford bull. A total of 8,065 records of birth weight and 7,380 records of preweaning daily gain and weaning weight were analyzed by derivative-free REML using a model that inc...

How and why cooperation evolves, particularly among nonrelatives, remains a major paradox for evolutionary biologists and behavioral ecologists. Although much attention has focused on fitness consequences associated with cooperating, relatively little is known about the second component of evolutionary change, the inheritance of cooperation or reciprocity. The genetics of behaviors that can onl...

We report the construction of a genetic linkage map of the mouse, consisting entirely of genetic markers that can be rapidly typed by polymerase chain reaction and that show a high degree of polymorphism among inbred laboratory strains. Specifically, the map contains 317 simple sequence length polymorphisms at an average spacing of 4.3 cM and is detectably linked to approximately 99% of the mou...

Current treatments have largely failed to slow the rapidly increasing world-wide prevalence of obesity and its co-morbidities. Despite a strong genetic contribution to obesity (40-70%), only a small percentage of heritability is explained with current knowledge of monogenic abnormalities, common sequence variants and conventional modes of inheritance. Epigenetic effects are rarely tested in hum...

background: heat stress is a common and usual problem in industries. several indices, including wet bulb globe temperature (wbgt), are used to evaluate heat stress. however, wbgt index has limitations such as high cost and response time. it is not thus suitable as a screening tool. heat strain scoring index (hssi) is also an observational-judgmental technique that has been developed for primary...

A procedure of intrafamilial immunization is described for production of antisera recognizing DL-A haplotypes. In a colony consisting of 1 sire, 6 bitches, and 67 offspring all haplotypes could be accurately allocated. In the colony the observed reaction frequencies of the antisera are in agreement with mendelian codominant inheritance. Mixed lymphocyte culture tests confirmed the accuracy of t...

Sex differences in ageing rates and lifespan are common in nature, and an enduring puzzle for evolutionary biology. One possibility is that sex-specific mortality rates may result from recessive deleterious alleles in 'unguarded' heterogametic X or Z sex chromosomes (the unguarded X hypothesis). Empirical evidence for this is, however, limited. Here, we test a fundamental prediction of the ungu...