OBJECTIVE Leptin therapy has been found to reverse hyperglycemia and prevent mortality in several rodent models of type 1 diabetes. Yet the mechanism of leptin-mediated reversal of hyperglycemia has not been fully defined. The liver is a key organ regulating glucose metabolism and is also a target of leptin action. Thus we hypothesized that exogenous leptin administered to mice with streptozoto...

AIM To study the protective effect of medicines on the formation of atherosclerosis in mice, it is needed to conduct the study in mice which is not genetically diabetic mice induced by streptozotocin (STZ) to produce hyperglycemia and atherosclerosis, compared with mice treated by yolk or its combination. MATERIAL AND METHODS Fifty-six mice, Double Deutch Webster strain, male, receive 10 week...

Peripheral neuropathy is one of the common complications of diabetes mellitus. It is frequently associated with debilitating pain. The present study was designed to investigate effect of Lycopene, a carotenoid found in tomatoes, on hyperalgesia and cold allodynia in streptozotocin (STZ) induced diabetic rats. After 4-weeks of STZ injection, diabetic mice exhibited a significant thermal hyperalg...

The objective of this study was to investigate the therapeutic efficacies of crude yam (Dioscorea batatas) powder (PY), water extract of yam (EY), and allantoin (the active constituent of yam) in streptozotocin (STZ)-induced diabetic rats with respect to glucose, insulin, glucagon-like peptide-1 (GLP-1), C-peptide, glycated hemoglobin (HbAlc), lipid metabolism, and oxidative stress. For this pu...

Submit Manuscript | http://medcraveonline.com Abbreviations: DM: Diabetes Mellitus; CVDs: Cardiovascular Diseases; PQQ: Pyrroloquinoline Quinone; LDH: Lactate Dehydrogenase; RR-value: Relative Risk Value; LPO: Lipid Peroxidation; LOOH: Lipid Hydroperoxide; HDL-C: High Density Lipoprotein; ROS: Reactive Oxygen Species; MDA: Malondialdehyde; STZ: Streptozotocin; PBS: Phosphate Buffered Saline; BS...

intracerebroventricular (icv) injection of streptozotocin (stz) in rats is followed by long-term and progressive deficits in learning, memory, and cognitive performance which is somewhat similar to sporadic alzheimer’s disease (sad). epidemiological studies suggest that non-steroidal anti-inflammatory drugs (nsaids) could delay or slow the clinical expression of sad. therefore, the beneficial e...

Objectives: This study aimed to evaluate the effect of anthocyanin on oxidative stress, sperm, and testis structure in diabetic rats induced by streptozotocin (STZ). Materials Methods: In this experimental research, diabetes was a single intraperitoneal injection STZ (50 mg/ kg). A total 64 were assigned into four groups as follows: control group, group daily administrated with at dose 100 mg/k...

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This based on classification related to pancreatic damage in total or partial so the impact insulin production. Glucose transporter a protein glucose uptake outside cell into and provides important role body's homeostasis. transporter-2 (GLUT-2) found pancreas, liver, kidney. Parameters used are expr...

Diabetic Neuropathy (DN) is one of the prevailing micro vascular complications diabetes which can be characterized by neuropathic pain. Streptozotocin (STZ) induced in rat has been increasingly used as a model painful diabetic neuropathy. STZ injection leads to neurotoxicity peripheral nerves that development Peripheral model. The present study was aimed at exploring protective role Tinospora c...