Stress-induced cardiomyopathy, also known as Takotsubo cardiomyopathy (TCMP) is characterized by a rapid, severe and usually reversible ventricular wall dysfunction, ST segment changes on EKG and troponin leak without evidence of obstructive coronary artery disease by coronary angiography. It represents approximately 1.2% of all troponin positive acute coronary syndromes [1]. Physical or emotio...

Stress-induced cardiomyopathy has a wide variety of clinical presentations ranging from angina symptoms to cardiogenic shock, as well as an array of echocardiographic findings and etiologies. We present a unique case of severe biventricular dilation with cardiogenic shock but rapid recovery within 96 hrs. Severe biventricular stressinduced cardiomyopathy secondary to acute rheumatoid arthritis ...

Takotsubo Syndrome is an acute heart failure that affects Predominantly posmenopausal women. It is similar to acute coronary syndromes with ST segment elevations, therefore, it’s estimated that 1% to 2% of all acute coronary syndromes are Takotsubo cardiomyopathy. There’s also a relation to physical and psychological stress factors, without an exact physiopathology [1]. A previous RETAKO trial,...

Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small heat shock protein alphaB-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of glucose 6-phosphate dehydrogenase (G6PD) and "reductive stress" (Rajasekaran e...

BACKGROUND Coronary artery fistula, first described by Krause in 1865, is an abnormal communication between the coronary artery and one of the four chambers of the heart or one of the great vessels. The communications are often congenital but may also be acquired from trauma or invasive cardiovascular procedures. Half of the cases present with angina pectoris whereas the remaining half are inci...

Evidence suggests that the autoimmune cardiomyopathy produced by a peptide corresponding to the sequence of the second extracellular loop of the beta(1)-adrenergic receptor (beta(1)-EC(II)) is mediated via a biologically active anti-beta(1)-EC(II) antibody, but the mechanism linking the antibody to myocyte apoptosis and cardiac dysfunction has not been well elucidated. Since the beta(1)-EC(II) ...

BACKGROUND Ischemia and tissue injury are common in patients with hypertrophic cardiomyopathy. Cardiovascular magnetic resonance imaging offers combined evaluations of each phenomenon at sufficiently high resolution to examine transmural spatial distribution. In this prospective cohort study, we examine the spatial distribution of stress perfusion abnormalities and tissue injury in patients wit...

A fifty-nine year old woman presented to a tertiary care center with a few hours of increasing chest pain suspicious for angina. She reported persistent bouts of nausea and vomiting for 2 days before the onset of chest pain, but denied abdominal pain or hematemesis. She denied any recent physical or emotional stressors. Notably, the patient was congenitally deaf, and all history was obtained th...

A fifty-nine year old woman presented to a tertiary care center with a few hours of increasing chest pain suspicious for angina. She reported persistent bouts of nausea and vomiting for 2 days before the onset of chest pain, but denied abdominal pain or hematemesis. She denied any recent physical or emotional stressors. Notably, the patient was congenitally deaf, and all history was obtained th...

A fifty-nine year old woman presented to a tertiary care center with a few hours of increasing chest pain suspicious for angina. She reported persistent bouts of nausea and vomiting for 2 days before the onset of chest pain, but denied abdominal pain or hematemesis. She denied any recent physical or emotional stressors. Notably, the patient was congenitally deaf, and all history was obtained th...