A patient with polycythemia vera who was treated with heparin for superficial septic thrombophlebitis developed heparin-induced thrombocytopenia and cerebral venous thrombosis with superior sagittal sinus occlusion 11 days after the institution of heparin therapy. We suggest that the severe thrombotic response to the heparin-induced platelet disorder in this patient occurred because the polycyt...

I T HAS BEEN proved by many authors that polycythemia induced by blood transfusion reduces the peripheral reticulocyte count and inhibits erythropoiesis. #{176} In previous investigations on erythropoiesis We have observed that polycythemia causes the appearance in the plasma of an active substance, which is antagonistic to erythropoietin. The plasma obtained from polycythemic animals was injec...

Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia. The efficacy in moderate hypoxemia (tension of arterial oxygen; on air, 7.4-8.0 kPa) was questioned by a recent large trial. We reviewed the evidence to date (five randomized trials; 1,191 participants, all with COPD). Based on the current evidence, the survival time may be improved in patient...

We describe the case of a young man with prolonged and severe chyluria from a previous parasitic infection. He presented with an acute myocardial infarction most likely secondary to increased clotting tendency. He had a spontaneously formed blood clot in his left anterior descending coronary artery. In the setting of hypo-albuminemia (which has occurred because of obligate losses of protein fro...

We describe a 38 year-old woman with polycythemia vera who presented with fulminant hepatic failure due to acute Budd-Chiari syndrome. She had a history of abdominal pain and distention for 4 days. Laboratory and clinical findings showed fulminant hepatic failure due to acute Budd-Chiari syndrome. Diagnosis was confirmed with abdominal ultrasonography and doppler ultrasonography showing ascites...

Serum erythropoietin (S-Epo) was measured with a radiommunoassay method in 36 patients with polycythaemia vera, 17 patients with secondary polycythaemia and 14 patients with relative polycythaemia. The diagnoses were made without the aid of the S-Epo values. It was found that Sment to normal haematocrit levels. the S-Epo levels remained subnormal in most of the polycythaemia vera patients even ...

Molecular genetic testing is a reliable method for the definitive diagnosis of polycythemia vera (PV). The use interferon preparations in addition to hydroxyurea and antiplatelet agents could be associated with better therapeutic outcomes. In this report, we present clinical case young patient asymptomatic PV demonstrate effectiveness molecular analysis diagnosis.

Bilateral adrenal hemorrhage (BAH) is a rare complication typically seen in critically ill patients, which can lead to acute adrenal insufficiency and death unless it is recognized promptly and treated appropriately. We describe the case of a 64-year-old man with polycythemia vera found to be unresponsive with fever, hypotension, tachycardia, and hypoglycemia. Electrocardiogram showed ST-elevat...

Illustration of DNA looping at the hemoglobin locus as a mechanism to reactivate fetal globin expression. Image inspired by the review article by Stefano Rivella from our new 'Leaders in Hematology' review series. 411 Ofatumumab and its role as immunotherapy in chronic lymphocytic leukemia Suneet Sandhu, et al. 415 Aging and blood disorders: new perspectives, new challenges D. Bron, et al. 418 ...