Zymogen granule (ZG) formation in acinar cells involves zymogen cargo sorting from trans-Golgi into immature secretory granules (ISGs). ISG maturation progresses by removal of lysosomal membrane and select content proteins, which enter endosomal intermediates prior to their apical exocytosis. Constitutive and stimulated secretion through this mechanism is termed the constitutive-like and minor-...

A resolving set for a graph Γ is a collection of vertices S, chosen so that for each vertex v, the list of distances from v to the members of S uniquely specifies v. The metric dimension of Γ is the smallest size of a resolving set for Γ. A graph is distance-regular if, for any two vertices u, v at each distance i, the number of neighbours of v at each possible distance from u (i.e. i−1, i or i...

Let Γ denote a D-bounded distance-regular graph, where D ≥ 3 is the diameter of Γ. For 0 ≤ s ≤ D − 3 and a weak-geodetically closed subgraph ∆ of Γ with diameter s, define a graph G(∆) whose vertex set is the collection of all weak-geodetically closed subgraphs of diameter s+2 containing ∆, and vertex Ω is adjacent to vertex Ω′ in G if and only if Ω∩Ω′ as a subgraph of Γ has diameter s+1. We sh...

In this paper we give a lower bound for the least distortion embedding of a distance regular graph into Euclidean space. We use the lower bound for finding the least distortion for Hamming graphs, Johnson graphs, and all strongly regular graphs. Our technique involves semidefinite programming and exploiting the algebra structure of the optimization problem so that the question of finding a lowe...

In this paper we generalize the absolute bound for association schemes to coherent configurations. We examine this bound in the context of quasi-symmetric and strongly regular designs. In particular, we use it to derive a new feasibility condition for strongly regular designs and give examples of parameter sets ruled out by this condition but which pass all other feasibility conditions known to...

We analyze when the Moore–Penrose inverse of the combinatorial Laplacian of a distance– regular graph is a M–matrix; that is, it has non–positive off–diagonal elements. In particular, our results include some previously known results on strongly regular graphs.

An important property of strongly regular graphs is that the second subconstituent of any primitive strongly regular graph is always connected. Brouwer asked to what extent this statement can be generalized to distanceregular graphs. In this paper, we show that if γ is any vertex of a distanceregular graph Γ and t is the index where the standard sequence corresponding to the second largest eige...

Antipodal covers of strongly regular graphs which are not necessarily distance-regular are studied. The structure of short cycles in an antipodal cover is considered. In most cases, this provides a tool to determine if a strongly regular graph has an antipodal cover. In these cases, covers cannot be distance-regular except when they cover a complete bipartite graph. A relationship between antip...

Let be an antipodal distance-regular graph of diameter 4, with eigenvalues θ0 > θ1 > θ2 > θ3 > θ4. Then its Krein parameter q4 11 vanishes precisely when is tight in the sense of Jurišić, Koolen and Terwilliger, and furthermore, precisely when is locally strongly regular with nontrivial eigenvalues p := θ2 and −q := θ3. When this is the case, the intersection parameters of can be parametrized b...