The intermediate nucleus of the lateral lemniscus (INLL) is a major input to the inferior colliculus (IC), the auditory midbrain center where multiple pathways converge to create neurons selective for specific temporal features of sound. However, little is known about how INLL processes auditory information or how it contributes to integrative processes at the IC. INLL receives excitatory proje...

The flow of cortical information through the basal ganglia is a complex spatiotemporal pattern of increased and decreased firing. The striatum is the biggest input nucleus to the basal ganglia and the aim of this study was to assess the role of inhibitory GABA(A) and glycine receptors in regulating synaptic activity in the dorsolateral striatum (DLS) and ventral striatum (nucleus accumbens, nAc...

Previously we have shown that strychnine-sensitive glycine-gated chloride channels (GlyRs) are functionally expressed by CA1 pyramidal cells and GABAergic interneurons in mature rat hippocampal slices. We now report that glycine application to dentate granule cells and hilar interneurons recorded in acute slices from adolescent rats elicits a strychnine-sensitive current similar to glycine-medi...

Moles are considered pests in Britain, but this issue has been little studied. Lower welfare standards have been tolerated for moles than for most other managed wild mammal species, as use of both the controversial poison, strychnine, and unregulated traps have been permitted. Strychnine was withdrawn in 2006 and there were fears that mole populations would increase as a result. In 2007, we con...

To what extent does corticocortical connectivity alone provide an explanation of the macro-scopical flow of activity recorded in the cerebral cortex of anesthetized cats? Different models of connectivity between cortical areas have been incorporated into a simple cortex model with binary activity states. We compare simple connection schemes (nearest-neighbor and nearest-neighbor-or-next-door-bu...

active facilitation. It might also be argued that the drug was operating on consolidation processes. Since it is generally assumed that consolidation is a progressive stabilization of a memory trace over time, our data suggest that this labile phase of memory lasts for at least 5 days. That there was a trend toward facilitation in the LD(l) group supports this contention. The same trend, howeve...