Vitamin B12 (B12) deficiency is known to be associated with various neurological manifestations. Although central manifestations such as dementia or subacute combined degeneration are the most classic, neurological manifestations also include sensory neuropathies. However, B12 deficiency is still rarely integrated as a potential cause of sensory neuronopathy. Moreover, as many medical condition...

Non-traumatic myelopathies represent a heterogeneous group of neurological conditions. Few studies report clinical and epidemiological profiles regarding the experience of referral services. Objective To describe clinical characteristics of a non-traumatic myelopathy cohort. Method Epidemiological, clinical, and radiological variables from 166 charts of patients assisted between 2001 and 2012 w...

Clinical copper deficiency is now more frequently recognized. Hematologically, it can present as anemia (microcytic, normocytic, or macrocytic) and neutropenia. Thrombocytopenia is relatively rare. Neurologically, it can manifest as myelopathy and peripheral neuropathy simulating subacute combined degeneration. Bone marrow findings can mimic myelodysplasia resulting in occasional inappropriate ...

BACKGROUND Vitamin B12 deficiency is known to produce a variety of neuropsychiatric manifestations including peripheral neuropathy, subacute combined degeneration of the spinal cord, optic atrophy, dementia, psychosis and mood disturbances. This case highlights seizures as yet another complication of vitamin B12 deficiency. Although unusual, this condition is nevertheless completely reversible ...

The treatment of subacute combined degeneration of the spinal cord (SCDSC) is based on a pretended etiological unity between the hematologic and neurologic manifestations, according to the old concept of the neuro-anemic syndrome. The first attempt of treatment of that disease was the liver therapy, introduced in 1926 by Minot and Murphy 2 3 , but the neurologic results did not correspond to th...

BACKGROUND It is believed that Pernicious anaemia (PA) is more common in the West. We postulate however that in India PA is probably an important aetiological factor as a cause of Vitamin B12 deficiency in patients having neurological disease. OBJECTIVE To investigate the aetiological factors resulting in Vitamin B12 (Vit B12) deficiency in patients with subacute combined degeneration (SACD) ...

A method for the measurement of serum folic acid activity is described, which is a modification of previous methods. The material in serum with activity for L. casei is made up of a stable and a labile component. The amount of stable component in normal subjects and patients with megaloblastic anaemia is similar. The amount of labile component varies. In patients with folic acid deficiency none...

A diffuse, chronic, superficial neocortical degeneration that resulted in atrophy was detected in five 1 to 2-year-old-dogs. Presenting neurologic signs included ataxia, dysphagia, blindness, and mentation changes. Magnetic resonance imaging on brains from 2 dogs demonstrated severe bilateral cerebrocortical atrophy and enlarged lateral and third ventricles. Grossly, multifocal, bilaterally sym...