objective(s): nanosilver is one of the most widely used nanomaterials due to its strong antimicrobial activity. thus, because of increasing potential for exposure of human to nanosilver, there is an increasing concern about possible side effects of these nanoparticles. in this study, we tested the potential dermal toxicity of nanosilver bandage on serum chemical biomarkers in mice.  materials a...

A.1 Toxicity to Birds / Reptiles ......................................................................................... 2 A.1.1 Birds: Acute Oral Studies .................................................................................... 2 A.1.2 Birds: Subacute Dietary Studies .......................................................................... 4 A.1.3 Birds: Chronic Studies.............

BACKGROUND Titanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs). OBJECTIVE To study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 ...

silver salts and nanosilver (ns) are the common antimicrobial used in the treatment of chronic wounds, so they are important to assess their dermal toxicity. therefore, in this study, the possible dermal toxicity of ns particles and silver nitrate (agno3), was tested by determining the serum level of transforming growth factor-β1(tgf-β1) and study on of mouse skin tissue. in this study, 30 balb...

conclusions about one-third of the patients referring to the pain clinic had subacute pain. the patients with chronic pain were older and more obese, had a higher prevalence of addiction, had more cases of knee pain, and reported more instances of obscure and persistent pain than those with subacute pain. objectives the aim of the present study was to assess and compare the sociodemographic cha...

Pavetta crassipes is a plant with many ethnomedicinal uses but has limited published data on its safety. The aim of the study was to evaluate subacute oral toxicity aqueous leaf extract P. in Wister rats. Thirty-six male rats were randomly divided into 6 groups six each. They treated with; 1 mL/kg distilled water (negative control group), (125, 250 and 500 mg/kg test respectively), 10 furosemid...

7.5% Hypertonic saline-6% Dextran-70 (HSD) is currently being evaluated in our laboratory as a resuscitation solution for the treatment of hypovolemia at a dose of 4 ml kg-1 body weight. A few reports of dextran toxicity, particularly of the kidney, have been cited in the literature, so the present study evaluated the acute and subacute toxicity of HSD administered i.v. to beagle dogs. In the a...

Silicon is the element very similar to carbon, and bioactive siliconized compounds have therefore received much attention. Siliconization of a compound enhances its biological activities. In the present study the hypolipidemic effect and toxicity of clofibrate and its siliconized analog, silafibrate, were compared. The experiments were performed in hypercholesterolemicWistar rats. Animals recei...