The aim of this study was to investigate the effects of elevated glucose concentrations on complement receptor- and Fcgamma receptor-mediated phagocytosis in normal human neutrophils. D-Glucose at 15 or 25 mM dose-dependently inhibited both complement receptor- and Fcgamma receptor-mediated phagocytosis, as compared to that at a normal physiological glucose concentration. The protein kinase C (...

The interactions of several beta-lactam antibiotics with the penicillin-binding proteins (PBPs) of Streptococcus pneumoniae have been studied using whole organisms treated with such antibiotics and subsequently with [3H]benzylpenicillin. Differences in chemical structure were shown to cause major and selective changes in the affinities of the beta-lactams for the PBPs Only 4 of the 28 compounds...

Cinoxacin is a new synthetic compound similar chemically and in antimicrobial activity to oxolonic acid and nalidixic acid. It is most effective against Escherichia coli and Proteus mirabilis, but at concentrations expected in the urine it is inhibitory for all species of Enterobacteriaceae. Relative to nalidixic acid, cinoxacin has slightly greater inhibitory and bactericidal activity, less in...

A survey of 303 urban and 156 rural children showed nasopharyngeal carriage of relatively resistant Streptococcus pneumoniae organisms in 14.2% and 19.2% of children, respectively. These organisms have minimum inhibitory concentrations for penicillin in the range of 0.12-1 microgram/ml. An analysis of 40 relatively resistant S. pneumoniae strains showed resistance to co-trimoxazole in 47.5%, tr...

The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of 40 lactobacillus strains were determined against six antibiotics with broad anaerobic spectra. Penicillin, ampicillin, clindamycin, and cephalothin were the most active inhibitory agents, with 95 to 100% of the strains inhibited at clinically achievable serum levels. However, despite the inhibitory ef...

The isoflavones daidzein and biochanin A induced a biphasic growth response in T-47D human breast cancer cells. At growth stimulatory concentrations, daidzein increased the percentage of cells entering the S phase, while at a growth inhibitory concentration, daidzein obstructed the progression of the cell cycle in the G2/M phase. Biochanin A regulated the cell cycle progression in a similar man...

We evaluated the inhibitory effects of pepstatin A and mefloquine on the in vitro and in vivo growths of Babesia parasites. The in vitro growth of Babesia bovis, B. bigemina, B. caballi, and B. equi was significantly inhibited (P < 0.05) by micromolar concentrations of pepstatin A (50% inhibitory concentrations = 38.5, 36.5, 17.6, and 18.1 μM, respectively) and mefloquine (50% inhibitory concen...

Turbid broth (0.5 ml) from blood culture bottles was inoculated into 0.5 ml of brain heart infusion broth, incubated for 3 to 6 h, diluted 1:500 in distilled water, and then inoculated directly into microtiter broth dilution susceptibility trays to test for minimal inhibitory concentrations. The results were compared to the standard tests performed 24 h later on colonies from subculture plates....

Certain tissue constituents inhibitory to cell growth, extracted from liver, are described. The findings indicate that inhibitory material is adsorbed to colloids in the native state and is freed from them by alcohol extraction. One inhibitor, ethanolamine, has been isolated. This substance differs in its biological properties from the bulk of the inhibitory material present in liver. Progress ...

The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) of 40 lactobacillus strains were determined against six antibiotics with broad anaerobic spectra. Penicillin, ampicillin, clindamycin, and cephalothin were the most active inhibitory agents, with 95 to 100% of the strains inhibited at clinically achievable serum levels. However, despite the inhibitory ef...