The effects of Hypericum perforatum (St John's wort) on morphine withdrawal syndrome and comparison with clonidine have been investigated in morphine-dependent rats. Adult male Wistar rats were subjects. The frequencies of withdrawal behavioral signs (rearing, teeth chattering and jumping) induced by naloxone challenge were demonstrated in morphine dependent rats receiving Hypericum perforatum ...

One-hundred-and-fifteen patients diagnosed as anxiety neurotics randomly received in a double blind study 20 mg clobazam (Frisium) as a single nightly dose (37 patients) or 10 mg b.d. (38 patients) or diazepam 5 mg b.d. (40 patients) for six weeks, followed by two weeks on placebo. Both the single and divided doses of clobazam were therapeutically equivalent to diazepam. After drug withdrawal, ...

PURPOSE OF REVIEW The demand for treatment for cannabis dependence has grown dramatically. The majority of the people who enter the treatment have difficulty in achieving and maintaining abstinence from cannabis. Understanding the impact of cannabis withdrawal syndrome on quit attempts is of obvious importance. Cannabis, however, has long been considered a 'soft' drug, and many continue to ques...

While vigabatrin-associated visual field constrictions have been generally considered irreversible, some case reports have raised the hope of partial improvement after drug withdrawal in occasional patients. Here we describe seven children with epilepsy, whose visual field constrictions, as demonstrated by the kinetic perimetry (Goldmann), attenuated or recovered after discontinuation of vigaba...

Perhaps one of the most frequently asked questions by the parents of children whose seizures are well controlled, is if—and when—medication can be discontinued. Many reasons may prompt this question; the need to continue taking drugs when the seizures appear to have stopped, the inconvenience of having to take—or give—regular medication even if only once a day, the development of not only recog...

The 2006 welfare reform legislation (Deficit Reduction Act of 2005) imposed more stringent work requirements and defined the amount of time cash assistance recipients are allowed to be exempted from the work requirement because of substance use treatment. As there is little empirical literature on the employability of substance users, it is difficult to know whether it is realistic to expect in...

Until 27 April 2006, the Netherlands Pharmacovigilance Centre Lareb received 7 reports of amenorrhea associated with the use of olanzapine. The time to onset varies from a few weeks to 10 months. The outcome was reported in 3 cases. One patient recovered after drug withdrawal and two patients did not recover; in one patient there was a dose increase to 15 mg once daily. In case D, hyperprolacti...

An increasing number of young people are becoming socially and economically marginalized in Japan under economic stagnation and pressures to be more globally competitive in a post-industrial economy. The phenomena of NEET/Hikikomori (occupational/social withdrawal) have attracted global attention in recent years. Though the behavioral symptoms of NEET and Hikikomori can be differentiated, some ...

Background Substance misuse by adolescents is associated with significant mortality and morbidity [1-9]. In spite of growing evidence on the effectiveness of Screening, Brief Intervention and Referral to Treatment (SBIRT) for adolescents [10-25], it has not been widely implemented in pediatric health-care settings. We describe implementation findings from a trial of different modalities of SBIR...