Electrochemical oxidation of some p-substituted phenols (p-nitrophenol, p-hydroxybenzaldehyde, phenol, p-cresol, and p-methoxyphenol) with electron-donating and -withdrawing substituents was studied to reveal the relationship between the structure and the electrochemical reactivity of p-substituted phenols using a boron-doped diamond electrode by voltammetry and bulk electrolysis. Voltammetric ...

An efficient and simple approach has been developed for the regio-selective synthesis of iodo-substituted dihydrofurans from amine substituted alkynols. The resulting iodo-substituted dihydrofurans have been further diversified by C-C couplings and C-N coupling reactions to afford a diverse range of substituted dihydrofuran derivatives.

A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a-e)/carbothioamides 8(f-j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a-e)/arylisothiocyanates 7(f-j) with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile (4). Compound 4 was s...

A novel series of sulpha/ substituted phenyl azo indoles is synthesised by the condensation reaction of N.phenacyl sulpha/ substituted phenyl amine with diazonium salt of sulpha/substituted benzene. They were characterized by IR, NMR and UV spectra and screened for their promising antituberculosis activity and antifertility activity. Keyword: indoles, sulpha/ substituted, drug, biological activ...

Copper-catalyzed direct annulation of α-substituted diazoacetates with 2-ethynylanilines leading to C2-functionalized indoles was achieved under mild reaction conditions. The C2-(carboxylate methyl) substituted indoles were obtained in moderate to high yields. In addition, this procedure tolerates a series of N-substituted and free substituted 2-ethynylanilines.

in this study, the radial distribution and gravimetric storage capacities of hydrogen on coronene (c24h12) and its si substituted forms, c24h12, c24-nsinh12 (n= 4-24), have been investigated at 298 k and 0.1 mpa (standard situation) using (n,v,t) monte carlo simulation by lennard-jones (lj) 12-6 potential. the results show that the increase of number of silicon substitution doesn’t have any eff...

A number of N-arylmethyl substituted indole derivatives have been synthesized and their effectiveness against ADP and arachidonic acid induced platelet aggregation in human plasma was determined. The desired compounds were synthesized by reacting the appropriate aniline derivative with isatin (or substituted isatin) to form the corresponding imine structures. The so formed compound was then act...

In the past few years multi component reactions have captured the attention of synthetic chemists as they provide  easy  access  to diverse  complex  organic molecules through  carbon -  carbon   and  carbon - heteroatom  bond  formations  in tandem manner with simple easy  to carry out  reaction  conditions in short  time. 1,8-dioxo-octahydroxanthene is a significant class of oxygen containing...