نتایج جستجو برای: subventricular tissue
تعداد نتایج: 920383 فیلتر نتایج به سال:
Solid tumors are a complex network consisting of cells at various stages of differentiation, neovasculature structures, reactive inflammatory cells, recruited cells and infiltrated parenchyma that interact within the tumor mass. However, evidence strongly indicates that cancer stem cells (CSCs) drive tumorigenesis, as these cells possess self-renewal and tumorigenic capacity absent in the major...
Neural precursor cells from adults have exceptional proliferative and differentiative capability in vitro yet respond minimally to in vivo brain injury due to constraining mechanisms that are poorly defined. We assessed whether cell cycle inhibitors that restrict stem cell populations in other tissues may participate in limiting neural stem cell reactivity in vivo. The cyclin-dependent kinase i...
In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of their regeneration potential. Migration of endogenous or grafted stem cells and neurons has been described in vertebrate brain, both under normal conditions from the subventricular zone along the rostral migratory stream and under pathophysio...
Nestin is an intermediate filament (IF) protein. These intermediate filament proteins are expressed mostly in neural stem cells [1-3]. Nestin is also expressed by many other stem cells and it is considered a primitive marker [4-7] . Upon differentiation, Nestin becomes down-regulated and is replaced by tissue-specific intermediate filament proteins [8]. During neuroand gliogenesis, Nestin is re...
The Subventricular Zone Neural Progenitor Cell Hypothesis in Glioblastoma: Epiphany, Trojan Horse, or Cheshire Fact? Iris C. Gibbs, MD,* Daphne Haas-Kogan, MD,y Stephanie Terezakis, MD,z and Brian D. Kavanagh, MD, MPHx Departments of Radiation Oncology, *Stanford University, Palo Alto, California; yUniversity of California, San Francisco; zJohns Hopkins University, Baltimore, Maryland; and xUni...
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity Erica Butti,* Marco Bacigaluppi,* Silvia Rossi, Marco Cambiaghi, Monica Bari, Arantxa Cebrian Silla, Elena Brambilla, Alessandra Musella, Roberta De Ceglia, Luis Teneud, Valentina De Chiara, Patrizia D’Adamo, Jose Manuel Garcia-Verdugo, Giancarlo Comi, Luca Muzio, Angelo Quattrini, Letizia Leocani,...
The adult human brain retains the capacity to generate new neurons in the hippocampal formation (Eriksson et al., 1998) and neuronal progenitor cells (NPCs) in the forebrain (Bernier et al., 2000), but to what extent it is capable of reacting to injuries, such as ischemia, is not known. We analyzed postmortem tissue from normal and pathological human brain tissue (n = 54) to study the cellular ...
Glucagon-like peptide-1 receptor (GLP-1R) activation by exendin-4 (EX-4) is effective in preclinical models of Parkinson's disease (PD) and appears to promote neurogenesis even in severely lesioned rats. In the present study, we determined the effects of EX-4 on cellular BrdU incorporation in the rat subventricular zone (SVZ) and substantia nigra (SN). We also determined the specificity of this...
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical. We transplanted neonatal cultured or primary rat cells from either the ventral subventricular zone (vSVZ) or the dentate gyrus (DG) into the adult rat...
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