We describe a case of vertebral osteomyelitis caused by Prevotella intermedia, which is an extremely unusual cause of vertebral osteomyelitis. The organism was isolated from vertebral biopsies and the patient was treated successfully with intravenous ampicillin-sulbactam and clindamycin. Diagnosis and management of this condition are described, and the importance of anaerobic bacteria in the pa...

The single-dose pharmacokinetics of intravenously administered cefoperazone (2.0 g) and sulbactam (1.0 g) were studied in normal subjects and in patients with various degrees of renal failure. In an open, parallel experimental design, six normal subjects (creatinine clearance, greater than 90 ml/min), two patients with mild renal failure (creatinine clearance, 31 to 60 ml/min), eight patients w...

Meningitis caused by Acinetobacter baumannii is rare and are mostly hospital acquired after neurosurgical procedure. We report a case of a 40-year old man was admitted to the intensive care unit due to subarachnoid haemorrhage. Our patient developed a ventriculitis due to A.baumannii treated successfully with sulbactam IV and intrathecal amikacin.

BACKGROUND The recommendations outlined in the latest guidelines published by the Surgical Infection Society (SIS) and the Infectious Disease Society of America (IDSA) regarding the proper duration of antibiotic therapy in patients with intra-abdominal infections are limited and non-specific. This ambiguity is due mainly to the lack of clinical trials on the topic of optimal duration of therapy...

From the PG Department of Pharmacology & *Department of Surgery, Govt. Medical College, Srinagar (Kashmir) J&K-India Correspondence to : Dr Vishal R. Tandon, Consultant/Lecturer-Pharmacology 5/B, Near Arya Samaj Bakshinagar Jammu-J&K-India 1800001 Prospective Randomized Open Labeled Study Comparing Prophylactic Efficacy of Parenteral Single Dose Cefuroxime vs Ampicillin-Sulbactam in Patients un...

Few effective therapeutic options are available for treating severe infections caused by extensively drug-resistant Acinetobacter baumannii (XDR-AB). Using a murine thigh-infection model, we examined the in vivo efficacy of colistin in combination with meropenem, tigecycline, fosfomycin, fusidic acid, rifampin, or sulbactam against 12 XDR-AB strains. Colistin, tigecycline, rifampin, and sulbact...

Introducción: la infección del tracto urinario es una patología frecuente. Aparece en todas las edades; principalmente mujeres sexualmente activas. Los microorganismos comúnmente aislados son Escherichia coli, Klebsiella spp, y Pseudomonas dependiendo de epidemiología factores riesgo. El manejo depende severidad sintomatología, ubicación el local; importantes al iniciar antibiótico empírico, qu...

U tract infections (UTIs) represent a widespread pathology for the medical practice and an important public health issue, frequently requiring hospitalization [1,2,8]. Klebsiella pneumoniae is one of the pathogen agents commonly involved in the etiology of UTIs [2,8] which currently presents altering of its sensitivity abstract. objective: This study aimed to determine and analyze the antibioti...

In vitro surveys of antimicrobial resistance among clinically important anaerobes are an important source of information that can be used for clinical decisions in the choice of empiric antimicrobial therapy. This study surveyed the susceptibilities of 556 clinical anaerobic isolates from four large medical centers using a broth microdilution method. Piperacillin-tazobactam was the only antimic...

The title compound, C(14)H(18)N(2)O(4)S, contains hydrogen-bonded dimeric pairs of mol-ecules arranged around inversion centers, forming 14-membered rings with an R(2) (2)(14) motif. The structure is stabilized by extensive intra-molecular inter-actions. The thia-zine ring adopts a half-chair conformation, with the S and N atoms displaced by -0.485 (3) and 0.296 (3) Å, respectively, from the pl...