Inhibitors of carbonic anhydrase (CA) have long been used as respiratory stimulants, most successfully in acute mountain sickness (AMS), but also in chronic obstructive pulmonary disease (COPD) and sleep-disordered breathing syndromes. Although effective, presently available inhibitors have minor annoying side-effects (paraesthesias, mild nausea and gastrointestinal discomfort) that can limit l...

A novel and simple approach to the synthesis of sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequently reacted with different sulphonamides to produce different sulfonylureas in excellent yields. The first reaction of diphenyl carbonate with amines was carried out in aqueous : organic (H2O : T...

' congestive or inflammatory' is used. It would seem that the word ' inflammatory' should be dropped as itis confusing to the student when trying to understand the difference between acute congestive glaucoma and iritis with secondary tension. In the chapter on ocular therapeutics it would be easier to remember doses if all examples of drops and ointments were given as made up to one ounce inst...

Since the advent of sulphonamides chemotherapy of cholera lias been intensely studied, but it has not yielded any uniform results. These drugs have been tried generally with the usual saline treatment but the outcome has been nothing like the dramatic effect as seen in bacillary dysentery. Fonno-cibazol was expected to be somewhat more effective but its value appears to be limited. Recently Chl...

The usefulness of sulphaguanidine in the treatment of cholera, especially in its early stage, was discussed in a previous paper published by the author (1945). The absorbable sulphonamides however do not appear to have been as yet much tried for the treatment of this disease. Hardy et al. (1943) and Hardy and Cummins (1943) published two papers indicating very good curative action of sulphadiaz...

Using intact bacterial cells, it was found that Pseudomonas aeruginosa was more susceptible to mafenide than Escherichia coli, that p-aminobenzoic acid (pABA) did not reverse or prevent inhibition by mafenide and that pABA itself was inhibitory. Under the experimental conditions used in these studies, pABA was more inhibitory to E. coli than to P. aeruginosa. It is proposed that pABA could be o...