ABSTRACTIntroduction: Cancer is caused by genetic abnormalities, such as mutation of ontogenesis or tumor suppressor genes which alter downstream signaling pathways and protein-protein interactions. Comparison of protein interactions in cancerous and normal cells can be of help in mechanisms of disease diagnoses and treatments. Methods: We constructed protein interaction networks of cancerous a...

In this paper, we defined a novel delta value di in molecular connectivity, and then obtained a novel kind of valence molecular connectivity index. The potential usefulness of the novel kind of valence molecular connectivity index in QSAR/QSPR is evaluated by its correlation with a number of molecules and by a favorable comparison with models based on molecular connectivity index. q 2003 Elsevi...

‎the second multiplicative zagreb coindex of a simple graph $g$ is‎ ‎defined as‎: ‎$${overline{pi{}}}_2left(gright)=prod_{uvnotin{}e(g)}d_gleft(uright)d_gleft(vright),$$‎ ‎where $d_gleft(uright)$ denotes the degree of the vertex $u$ of‎ ‎$g$‎. ‎in this paper‎, ‎we compare $overline{{pi}}_2$-index with‎ ‎some well-known graph invariants such as the wiener index‎, ‎schultz‎ ‎index‎, ‎eccentric co...

Topological indices are numeric values associated with a graph and characterize its structure. There various topological in theory such as degree-based, distance-based, counting-related indices. Among these indices, degree-based very interesting studied well literature. In this work, we the generalized form of harmonic, geometric-arithmetic, Kulli–Basava power-sum-connectivity index for special...

The eccentricity of a vertex is the maximum distance from it to another vertex and the average eccentricity ecc(G) of a graph G is the mean value of eccentricities of all vertices of G. The average eccentricity is deeply connected with a topological descriptor called the eccentric connectivity index, defined as a sum of products of vertex degrees and eccentricities. In this paper we analyze ext...

In this note, we derive the lower bound on the sum for Wiener index of bipartite graph and its bipartite complement, as well as the lower and upper bounds on this sum for the Randić index and Zagreb indices. We also discuss the quality of these bounds.