Using first-order derivative techniques, a simple accurate and precise Ultraviolet spectrophotometric method was developed for the determination of solifenacin succinate tamsulosin hydrochloride in combined dosage form. Every solifinacin scanned wavelength region 200-400 nm sampling wavelengths selected were selected. Sampling chosen at 265 (zero crossing succinate) where absorbance important 2...

RATIONALE Drug-induced bilateral angle-closure glaucoma is a rare event and should be treated correctly and promptly to prevent visual loss. PATIENT CONCERNS We report a rare case of sumatriptan-induced bilateral angle-closure glaucoma in a young woman with migraine, and explore the possible mechanism. DIAGNOSES We describe the clinical outcome of a patient with sumatriptan-induced bilatera...

Migraine is a chronic, painful, and often disabling primary headache disorder, typically presenting with recurrent attacks that may be accompanied by a variety of neurological, gastrointestinal, and autonomic symptoms. Gastrointestinal symptoms in association with migraine including, nausea, vomiting, and gastroparesis, affect a large proportion of migraine sufferers. These symptoms may result ...

BACKGROUND Triptan's efficacy in the treatment of migraine has never been reported in Taiwanese. A high placebo effect was reported in Japanese. The objective of this study was to evaluate the efficacy of intranasal sumatriptan in the acute treatment of migraine in Taiwanese patients. METHODS Fifty-eight patients who had experienced migraine for at least 1 year were randomly assigned to 2 gro...

Serotonin (5-HT) modulates pain and anxiety from within the midbrain periaqueductal gray (PAG). In the present study, the effects of 5-HT- and 5-HT(1/2) subtype-selective ligands on rat PAG neurons were examined using whole cell patch-clamp recordings in brain slices. In voltage clamp, 5-HT produced outward and inward currents in distinct subpopulations of neurons that varied throughout differe...

• Triptans (5-HT1B/1D-agonists) perform better if they are taken at the start of a migraine attack, as long as the headache is of mild or moderate intensity (⇑⇑). This recommendation to take triptans if the headache is mild only applies for patients who can differentiate migraine attacks from tension headaches. • The presence of allodynia (touch is perceived as painful) in the area of the face ...