Candida species are common human fungal pathogens causing a wide range of clinical diseases, ranging from superficial infections to life-threatening systemic disease. Superficial infections include vaginal candidiasis which affects over 75% of women during their lifetime with 5% of women suffering debilitating recurrent infections. Life-threatening systemic Candida disease is the fourth most co...

To evaluate the efficacy of itraconazole capsules in prophylaxis for fungal infections in neutropenic patients, we conducted a prospective, double-blind, placebo-controlled, randomized trial. Patients with hematologic malignancies or those who received autologous bone marrow transplants were assigned either a regimen of itraconazole (100 mg orally twice daily; n=104) or of placebo (n=106). Over...

Prevalence of superficial and systemic mycoses has increased in recent years. The most common etiological factors responsible for those infections are fungi of the genus Candida, mainly Candida albicans; however approximately 35–65% of candidemia cases are caused by other species of this particular genus, described in literature as Candida non-albicans pathogens. Fungal infections have deleteri...

results presence of soy pc improved mechanical properties, lowered swelling ratio and increased stability of the films. solubilizing activity of phospholipid resulted in higher flux of drug release from formulation containing higher amount of soy pc. antifungal efficacy of formulations was confirmed against two species of dermatophytes in vitro. conclusions this topical composite film had the p...