Adaptor proteins allow temporal and spatial coordination of signalling. In this study, we show SUMOylation of the adaptor protein TANK and its interacting kinase TANK-binding kinase 1 (TBK1). Modification of TANK by the small ubiquitin-related modifier (SUMO) at the evolutionarily conserved Lys 282 is triggered by the kinase activities of IκB kinase ɛ (IKKɛ) and TBK1. Stimulation of TLR7 leads ...

A conceptually simple method for linac tuning has been tested on the 200 MeV drift-tube linear accelerator at Fermilab. The phase of a beam-induced signal in a stripline detector is measured as tank phase is scanned over approximately 360 degrees. The stripline detector is downstream of the tuned tank. The resulting phase-scan curves have unique signatures that depend upon only a few critical p...

In this study, a Multi-objective Optimization Model (MOM) is developed and solved for the optimum design of surge protection devices (including air chamber shock damper) with conflicting goals. The damper new type tank invented by researchers. For first time, parameters as decision variables are raised in MOM problem, results benchmarked solving model well. Method characteristics (MOC) chosen n...

Until now, clinicians have been relying solely on LH activity-dependent triggering of final oocyte maturation and thus taken it for granted that the natural midcycle FSH surge is biologically redundant. However, it is time to question this paradigm. Evidence from clinical studies hint that in a yet-to-be-defined subset of patients, dual LH and FSH surge is advantageous compared with LH-only sur...

Adopting adequate operational and safety measures is a significant part of the investigation transient processes hydropower plants (HPPs), both throughout design stage prospective planning HPPs envisaged for refurbishment/uprating. One surge tank (ST) types, insufficiently researched so far, with potential positive techno-economical influence, semi-pneumatic (SPST). Since detailed analyses SPST...

Elimination of tank overfills is a significant problem for the petroleum industry. Since most tank receiving operations are manual, the operators rely heavily on tank level gauges and alarms for overfill prevention. Tracing the historical development of tank gauging and alarm systems provides insight into why independence is so important. This history is interwoven with interpretations, insight...

The novel ultrasonic NDT technique based on application of long range guided waves is proposed for detection of defects in a storage tank floor. The technique needs access only to the outer edge of the tank floor and do not require emptying and cleaning inside of the tank. The technique has been developed on the basis of the Lamb wave transmission tomography. The propagation of the guided waves...

this paper deals with an inspection of defects including corrosion and leakage by acoustic emission (ae) in an oil tank floor. in contrast to intrusive methods such as magnetic flux leakage, eddy current or ultrasonic, there is no need to emptying and entering the tank in ae method in order to inspection. in this research ae investigation and ae source location is presented in detail. the resul...

This paper presents a new analysis of the effects of ambient temperature variations on the surge characteristics of turbo heat pumps. To this end, an analytical model capable of predicting unsteady behavior of surge in turbo heat pumps has been developed. In compression systems, surge is mostly caused by the compressor work exceeding the mechanical inertia of the system. In refrigeration system...