BACKGROUND AND PURPOSE MR gradient echo imaging is sensitive to the magnetic susceptibility of different tissue types. The purpose of this study was to investigate the diagnostic potential of MR phase imaging of the human brain. METHODS High-spatial-resolution, T2*-weighted, single-echo images were acquired in five volunteers and one patient with a brain tumor on a 1.5T system by applying a 3...

A 59-year-old man with a family history of cerebral cavernous malformations (CCM) presented with focal seizures. T2*-weighted gradient echo (GRE) images showed multiple lesions consistent with cavernous malformations (figure 1). Susceptibility-weighted images (SWI) detected nearly triple the number of lesions than were seen with the GRE sequence (figure 2). SWI is a relatively new MRI technique...

Chromatin structure and its changes or maintenance throughout developmental checkpoints play indispensable role in organismal homeostasis. Chromatin remodeling factors of the SWI/SNF2 superfamily use ATP hydrolysis to change DNA-protein contacts, and their loss-of-function or inappropriate increase leads to distinct human pathologic states. In this review, we focus on the translational view of ...

Introduction: Two techniques have been presented in the last year to acquire both angiographic and venographic information in a single acquisition (MRAV) using susceptibility weighted imaging (SWI). One uses a double echo approach with the shorter echo used for the angiography and the longer echo used for the venography (1). The other uses a single echo that is a compromise between the two with...

BACKGROUND AND PURPOSE Enhancing lesions on brain MR imaging can present a diagnostic quandary as both benign lesions such as brain capillary telangiectasia and pathologic lesions such as demyelination may appear similar. Stagnation of blood in low-flow venous channels of brain capillary telangiectasias results in susceptibility effect secondary to the increased local deoxyhemoglobin. Both T2* ...

Introduction: Susceptibility weighted imaging (SWI) has been used for some time as a means to enhance venous vessels using high pass filtered phase images [1,2]. However, efficacy of SWI processing relies especially on an asymmetric voxel aspect ratio [3] and to a slight extent on the relative orientation of the head and the main magnetic field. Therefore, when SWI is collected as high resoluti...

Susceptibility-weighted imaging (SWI) is a high spatial resolution, three-dimensional (3D), gradientecho (GRE) magnetic resonance (MR) technique [1]. It uses both the T2*-weighted magnitude and the phase information to emphasize the magnetic susceptibility differences of various tissues or substances, such as blood products, iron, and calcification, by post-processing the magnitude images with ...

Precise preoperative identification of the collateral venous anastomoses is critical for proper surgical management of patients with meningioma involving sinus. This study was to assess the feasibility of susceptibility weighted imaging (SWI) to delineate the collateral venous anastomoses before surgery. Twenty-five patients with meningiomas that were involved in sinuses underwent surgery and t...

The SWI/SNF complex disrupts and mobilizes chromatin in an ATP-dependent manner. SWI/SNF interactions with nucleosomes were mapped by DNA footprinting and site-directed DNA and protein cross-linking when SWI/SNF was recruited by a transcription activator. SWI/SNF was found by DNA footprinting to contact tightly around one gyre of DNA spanning approximately 50 bp from the nucleosomal entry site ...