Amyotrophic lateral sclerosis (ALS), the most prevalent type of motor neuron disease in adults, affecting 4–6 per 100,000, is a fatal neurodegenerative disease. ALS is characterized by the degeneration of both upper motor neurons comprising the corticospinal tract and lower motor neurons arising from the brainstem nuclei and ventral roots of the spinal cord. The only drug approved for ALS—riluz...

Abstract To minimize the cost and power consumption of PDP TV, a practical sustain circuit topology is presented with an address-and-display-period-separated driving scheme. The proposed sustain driver employs bidirectional switches to reduce the number of components. Operational principles and corresponding features are illustrated and compared with the conventional approach. The valuable cont...

Astrocytes provide metabolic substrates to neurons in an activity-dependent manner. However, the molecular mechanisms involved in this function, as well as its role in synaptic transmission, remain unclear. Here, we show that the gap-junction subunit proteins connexin 43 and 30 allow intercellular trafficking of glucose and its metabolites through astroglial networks. This trafficking is regula...

Attention-deficit/hyractivity disorder (ADHD) is a developmental disorder with the cardinal features of difficulties with sustained attention, distractibility, hyperactivity, and impulse control. It arises early in childhood, typically between 3 and 7 years of age. The disorder is relatively stable over time and persists through adolescence and into adulthood in more than half the cases. A sign...

Behavioral inhibition (BI) is a risk factor for anxiety disorders. While the two constructs bear behavioral similarities, previous work has not extended these parallels to the neural level. This study examined amygdala reactivity during a task previously used with clinically anxious adolescents. Adolescents were selected for enduring patterns of BI or non-inhibition (BN). We examined amygdala r...

Attentional processes in individuals with high-functioning autism were compared with a matched control group. Participants for the study were 103 children and adults with autism and 103 control subjects. Measures administered corresponded to Mirsky et al.'s (1991) factor analysis of tests of attention. Diminished performance was noted on measures that loaded on the Focus-Execute and Shift facto...

This paper traces the trajectory of scholarship on settler colonial city and argues that this literature could pay closer attention to dynamic circulations, movements, mobilities constitute sustain urban space. It foregrounds ways movement commodities, capital, people must be assiduously managed in order preserve relations beyond. Building existing work, it “settler urbanism” operates as a regi...