نتایج جستجو برای: sustained release floating tablet

تعداد نتایج: 335165  

Journal: :International Journal of Applied Pharmaceutics 2021

Objective: Focus of the study was to formulate Design expert Software assisted floating tablet Bisoprolol Fumarate. Fumarate is a Beta adrenergic blocking agent, used treat cardiac diseases favorable characters be formulated as sustained release Gastro retentive tablets.
 Methods: Floating Tablets were prepared by using polymers such Polyox N 12 K and Carbapol 940 P. Formulations direct co...

2011
Swati Jain Neelesh Kumar Mehra Akhlesh Kumar Singhai Gaurav Kant Saraogi Lakshmi Narayan

The study was obtained to develop oral controlled release matrix tablets of Lamivudine having different proportion of Guar gum (retardant polymer) and to study the effect of formulation factor such as polymer proportion on the invitro release. The prepared granules were evaluated such as angle of repose, loose bulk density, tapped bulk density and compressibility index and satisfactory results ...

2014
Shivani Patel Mihir Patel

The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Development of sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeuti...

2014
Wei Li Lee Jun Wei Melvin Tan Chaoyang Nicholas Tan Say Chye Joachim Loo

Floating dosage forms with prolonged gastric residence time have garnered much interest in the field of oral delivery. However, studies had shown that slow and incomplete release of hydrophobic drugs during gastric residence period would reduce drug absorption and cause drug wastage. Herein, a spray-coated floating microcapsule system was developed to encapsulate fenofibrate and piroxicam, as m...

Journal: :Advanced pharmaceutical bulletin 2016
Md Lutful Amin Tajnin Ahmed Md Abdul Mannan

PURPOSE The purpose of this study was to develop and evaluate metronidazole loaded floating-mucoadhesive microsphere for sustained drug release at the gastric mucosa. METHODS Alginate gastroretentive microspheres containing metronidazole were prepared by ionic gelation method using sodium bicarbonate as gas forming agent, guar gum as mucoadhesive polymer, and Eudragit L100 as drug release mod...

2014
Kondi Vanitha Mohan Varma Alluri Ramesh

Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy. The purpose of this study was to optimize and evaluate floating tablets of hydralazine hydrochloride designed to prolong the gastric residence time and to pro...

2013
Anupam Sarma Pulak Deb Suvakanta Dash

The expense and complications in new drug entities have increased since last 3 decades, with concomitant recognition of the therapeutic advantages of controlled drug delivery. So focus has been given on development of sustained or controlled release drug delivery systems. Bilayer tablet is new novel of tablet for the successful development of controlled release formulation along with various fe...

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2015
A-K Vynckier H Lin J A Zeitler J-F Willart E Bongaers J Voorspoels J P Remon C Vervaet

In this study calendering is used as a downstream technique to shape monolithic co-extruded fixed-dose combination products in a continuous way. Co-extrudates with a metoprolol tartrate-loaded sustained-release core and a hydrochlorothiazide-loaded immediate-release coat were produced and immediately shaped into a monolithic drug delivery system via calendering, using chilled rolls with tablet-...

2011
G. Rajalakshmi R. Balachandar N. Damodharan

In the present study sustained release matrix tablets of Theophylline were prepared by direct compression method using different grades and ratios of hydroxy propyl methyl cellulose in presence of ethyl cellulose to examine their influence on tablet properties and drug release profile. Theophylline is used to treat chronic obstructive pulmonary disease (COPD) and asthma. The drug has a narrow t...

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