To investigate the mechanism of allosteric switching in human hemoglobin, we have studied the dissociation of the ligand (CO) from several intermediate ligation states by a stopped-flow kinetic technique that utilizes competitive binding of CO by microperoxidase. The hemoglobin species investigated include Hb(CO)4, the diliganded symmetrical species (alpha beta-CO)2 and (alpha-CO beta)2, and th...

In this paper we present the generalization of the test sequencing problem, originally defined for symmetrical tests, that also covers asymmetrical tests. We prove that the same heuristics that has been employed in the traditional solution of the problem (e.g., the AO∗ algorithm with heuristics based on Huffman’s coding) can be employed also for the generalized case. Examples are given to illus...

Background: The aim of the study was to evaluate the magnetic resonance imaging (MRI) findings in bilateral symmetrical Hirayama disease and find out MRI features which are probably more indicative of symmetrical Hirayama disease, thereby help in differentiating this entity from other motor neuron disease (MND). Methods: This prospective as well as retrospective study was carried out from Decem...

The movement correlates of unit activity in medullary reticular formation cells were observed in unrestrained cats. Fifty-four percent of these cells had "laterally asymmetrical" movement relations and 38% had "laterally symmetrical" movement relations. All cells that discharged in relation to active lateral movement of the spinal column discharged preferentially in relation to ipsilateral move...

A multilevel inverter is capable of generating high-quality stepwise pseudo-sinusoidalvoltage with low THD , applicable to high-power and high-voltage systems. These types of topologiesmay require a large number of switches and power supplies. This leads to much cost, large size, andcomplicated control algorithms. Thus, newer topologies are being proposed to decrease the numberof power electron...

angular deformities of the lower limbs are common during childhood. in most cases this represents a variation in the normal growth pattern and is an entirely benign condition. presence of symmetrical deformities and absence of symptoms, joint stiffness, systemic disorders or syndromes indicates a benign condition with excellent long-term outcome. in contrast, deformities which are asymmetrical ...

In this paper, a new configuration for symmetrical and asymmetrical multilevel inverters is proposed. In asymmetric mode, different algorithms are suggested in order to determine the magnitudes of DC voltage sources. The merit of this topology to the conventional symmetric and asymmetric inverters is verified by the provided comparisons. This topology uses a lower number of power electronic dev...

We examine the relation between the phase-coherent processes and spin-dependent thermoelectric effects in an Aharonov-Bohm (AB) interferometer with a Rashba quantum dot (QD) in each of its arm by using the Green's function formalism and equation of motion (EOM) technique. Due to the interplay between quantum destructive interference and Rashba spin-orbit interaction (RSOI) in each QD, an asymme...