the paranasal sinuses are known to be a rare location for metastasis. renal cell carcinoma (rcc) is the most frequent primary tumor to metastasize to the sinonasal region, followed by lung and breast cancer. in particular, clear cell type rcc, which represents approximately 85% of rccs, is characterized by early metastasis, and it sometimes spreads to unusual sites (1, 2). metastatic tumors in ...

BACKGROUND Recurrent periorbital tumors pose management challenges because they are often unresectable and chemorefractory. Proximity to critical structures renders reirradiation difficult. With image-guided intensity-modulated radiation therapy (IG-IMRT), real-time corrections to patient setup are possible, enabling significant shrinkage of planning target volume margins and safe dose escalati...

Background CRSwNP(Chronic rhinosinusitis with nasal polyps) is characterized with eosinophil infiltration into sinonasal tissues in Caucasian patients. In Japan, this condition was thought to be an infectious disease (so called “empyema”) for a long time. However, after a clinical profile of ECRS(eosinophilic chronic rhinosinusitis) was first introduced by Moriyama in 2002, the prevalence of EC...

BACKGROUND Microbes and allergens can stimulate the nasal mucosa, potentially leading to the development of acute bacterial rhinosinusitis (ABRS). This study was designed to determine if allergen exposure alters the sinonasal microbiome. METHODS We performed a parallel observational study of healthy adults with seasonal allergic rhinitis (SAR; grass or tree, n = 20) or nonallergic subjects (n...

Introduction: Plasmacytoma is a monoclonal proliferation of plasma cells. It can be an isolated lesion, for which the term extramedullary plasmacytoma is used, or a representation of multiple myeloma.The upper respiratory tract is the most common site for an extramedullary plasmacytoma. Sinonasal plasmacytomas cause different symptoms depending on the sites of origins and the areas of involveme...

BACKGROUND Mucosal melanoma is a rare malignancy arising from melanocytes of the mucosal surfaces. The pattern and frequency of oncogenic mutations and histopathological biomarkers have a role on distinct tumour behaviour and survival. AIMS To assess the rate of C-KIT positivity and its effect on survival of surgically treated sinonasal malignant melanoma patients with other histopathological...