In the last decade, cumulative evidence suggests that systemic inflammation is closely related to oncologic outcomes in patients with cancer. This has been demonstrated by a strong correlation between the degree of systemic inflammatory response and poor oncologic outcomes in a variety of malignancies. Several systemic inflammatory markers have been studied and, of those, neutrophilto-lymphocyt...

The past few decades have seen an increase in both the role and the complexity of neoadjuvant therapy for breast cancer. Neoadjuvant therapy was initially described as systemic chemotherapy for inflammatory or locally advanced breast cancer but now entails a combination of chemotherapy, endocrine therapy, and targeted therapy. Neoadjuvant systemic therapy is employed for inoperable inflammatory...

Hepatocellular carcinoma (HCC) ranks as the eighth most common cancer in the world. Although uncommon in North America, the incidence of HCC in the United States has increased by 70% since the 1980s (Yu, Yuan, Govindarajan, & Ross, 2000). The most frequent causes of malignant hepatic disease in the United States are metastases from melanoma and primary tumors of the gastrointestinal tract, brea...

Oral health is a reflection of systemic health. The various nutritional deficiencies not only affect the but also have an impact on oral prevalence Vitamin D deficiency (VDD) rampant globally. (VD) essential for skeletal growth during childhood and adulthood has great tissues odontogenesis. VDD several implications from to adulthood. VD can negatively influence mother child supplementation brin...

Considerable research is aimed at determining the mechanism by which tumor cures, or regrows or second cancer develops, to be predictable and controllable. The wide range of doses, from low to very high, estimated statistically is responsible for such risks. A mathematical model is presented that describes both: the growth due to lower or over irradiated doses or the post therapy relapse of hum...

this paper describes one university’s approach to improving the quality of teaching and learning at the institutional level, based on the premise of improving the design of curriculum rather than focusing on the skills of teachers as such. the paper describes the process by which university-wide principles of curriculum design were defined and agreed, as well as the parallel campaigns needed to...

Mis-expression of microRNAs (miRNA) is widespread in human cancers, including in pancreatic cancer. Aberrations of miRNA include overexpression of oncogenic miRs (Onco-miRs) or downregulation of so-called tumor suppressor TSG-miRs. Restitution of TSG-miRs in cancer cells through systemic delivery is a promising avenue for pancreatic cancer therapy. We have synthesized a lipid-based nanoparticle...

TLR agonists have demonstrated anti-tumor activity in both animals and humans. Clinically, successful antitumor activity with TLR agonists was most often observed when the molecules were applied locally to dermatological cancers. This mode of administration was also associated with fewer and less severe adverse events (AEs) when compared to systemic administration. The efficacy of TLR agonists ...