BACKGROUND Cognitive problems in breast cancer patients are common after systemic treatment, particularly chemotherapy. An increasing number of fMRI studies show altered brain activation in breast cancer patients after treatment, suggestive of neurotoxicity. Previous prospective fMRI studies administered a single cognitive task. The current study employed two task paradigms to evaluate whether ...

Although central nervous system (CNS) leukemic relapse is frequent in adult acute lymphocytic leukemia (ALL), the need for prophylaxis in different risk groups for CNS relapse, the value of high-dose systemic and intrathecal (IT) chemotherapy, and the timing of prophylaxis are not well defined. This analysis was conducted to investigate these questions and to assess the value of a risk-oriented...

Objective To examine the effectiveness of systemic chemotherapy following radical hysterectomy for women with intermediate-risk stage IB cervical cancer. Materials and Methods This is a retrospective analysis of a previously organized nation-wide cohort study examining 6,003 women with stage IB-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2008 in Japan. Survival of ...

Patients with brain metastases represent a heterogeneous group where selection of the most appropriate treatment depends on many patient- and disease-related factors. Eventually, a considerable proportion of patients are treated with palliative approaches such as whole-brain radiotherapy. Whole-brain radiotherapy in combination with chemotherapy has recently gained increasing attention and is h...

Head and Neck Cancer (HNC) is a broad category of cancer, comprises cancer that origin into oral cavity, pharynx, larynx, sinuses salivary gland. Majority cases reported in Pakistan are metastatic to with morphology squamous cell carcinoma. Locally advance, un-resectable tumors treated systemic therapies. Commonly prescribe therapies includes chemotherapy targeted therapy. However, the most pre...

Isolated metastases to the thyroid gland are rare. It is not common for lung cancer metastasize gland, and when it metastasizes; predominant pathology usually adenocarcinoma. In this article, a rare case of metastasis from squamous cell presented. A forty-four-year-old male patient diagnosed with Stage III in our clinic. After chemotherapy, nodular lesion detected. Through fine needle aspiratio...

abstract cytomegalovirus (cmv) is a virus that can be consider as invasive infection after transplantation or chemotherapy, long-term corticosteroid users or in immunodeficient patients such as hiv. different complications were seen in immunocompetent patients but colitis rarely occurs. the diagnosis of cmv was based on pathology by colonoscopy, positive cmv antigen and high cmv-igm titer serum...