CONTEXT In traditional system of medicine brahmi has been used to enhance memory. Recently it has been reported to have action in psychiatric disorders. With these backgrounds the work has been undertaken to study antidepressant activity of brahmi in albino mice. AIM To evaluate antidepressant activity of brahmi in experimental models. MATERIALS AND METHODS The antidepressant activity was s...

Objectives: The Porsolt test and the tail suspension test were performed on mice to investigate possible mood effects of parecoxib, and to assess the interactions between this agent and antidepressants belonging to two different classes. Materials and methods: In the Porsolt test, parecoxib was given in geometric progression doses (ratio 2), in order to assess the depressant/antidepressant effe...

OBJECTIVES This study planned to assess antidepressant like activity of aqueous extract from leaves of Citrus maxima Merr. (Rutaceae). MATERIALS AND METHODS Boiling was used for aqueous extraction. Acute toxicity study was performed in mice. Antidepressant activity was studied using locomotor activity test, modified forced swimming test (FST) and tail suspension test (TST). Three doses 100, 2...

The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitoster...

Recent findings support the hypothesis that CB receptor blockade might be associated with antidepressant and anti-stress effects. In the current study, the anti-depressant-like effects of rimonabant were studied in validated models of depression. Rimonabant (4-8mg/kg, i.p.) significantly decreased the duration of immobility in a dose dependent manner in mice forced swim test (FST) and in tail s...

The neurogenesis hypothesis of major depression has two main facets. One states that the illness results from decreased neurogenesis while the other claims that the very functioning of antidepressants depends on increased neurogenesis. In order to verify the latter, we have used cyclin D2 knockout mice (cD2 KO mice), known to have virtually no adult brain neurogenesis, and we demonstrate that t...

The aim of the present study was to evaluate the antidepressant activity of the ethanolic extract of roots of Hibiscus rosa sinensis (HRS). The extract was tested on rats and mice at doses level of 250 and 500 mg/kg, Fluoxetine was used as a standard drug at dose of 15 mg/kg, by using forced swimming test, tail suspension test and open field test. HRS extract at dose level of 500 mg/kg caused h...