in this study a sensitive, simple and accurate spectrophotometric method was suggested for determination of tamsulosin in bulk powder and pharmaceutical dosage form based on the formation of an ion-pair complex between the drug and bromocresol green in a buffer solution at ph 3.5. the formed yellow color complex was extracted with chloroform and measured at 415 nm. the optimum reaction conditio...

A. Alpha adrenergic blockers (alfuzosin, doxazosin, silodosin, tamsulosin, and terazosin) B. Hormonal manipulation (including finasteride, dutasteride, and dutasteride plus tamsulosin) C. Interstitial laser coagulation of the prostate (ILCP) D. Laser prostatectomy E. Laser based procedures including contact laser ablation of the prostate (CLAP), holmium laser procedures of the prostate (HoLAP, ...

OBJECTIVES To compare the efficacy of silodosin (8 mg) vs tamsulosin (0.4 mg), as a medical expulsive therapy, in the management of distal ureteric stones (DUS) in terms of stone clearance rate and stone expulsion time. PATIENTS AND METHODS A prospective randomised study was conducted on 115 patients, aged 21-55 years, who had unilateral DUS of ⩽10 mm. Patients were divided into two groups. G...

OBJECTIVES To investigate the add-on effect of solifenacin for Japanese men with remaining overactive bladder (OAB) symptoms after tamsulosin monotherapy for lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) in real-life clinical practice. METHODS Patients aged ≥ 50 having remaining OAB symptoms (≥ 3 of OAB symptom score (OABSS) with ≥2 of urgency score) aft...

We evaluated the short-term effects of tamsulosin in treating benign prostatic hyperplasia. Twenty-seven patients, aged 57 to 86 years (mean 68.4); complaining of obstructive urinary symptoms who had received no previous treatment for such symptoms were orally administered 0.2 mg of tamsulosin for 4 weeks. Symptoms (total AUA symptom score and AUA symptom subscores) and objective parameters inc...

Benign prostatic hyperplasia (BPH) is a complex disease that is progressive in many men. BPH is commonly associated with bothersome lower urinary tract symptoms; progressive disease can also result in complications such as acute urinary retention (AUR) and BPH-related surgery. It is therefore important to identify men at increased risk of BPH progression to optimise therapy. Several factors are...

Objective: The objective of study was to determine the efficacy of Tamsulosin (alpha blocker) in spontaneous expulsion of 4-7mm ureteric stones in the distal segment of the ureter. Subjects and methods: This randomized controlled trial study was conducted in the department of Urology, Shaikh Zayed Hospital between 24 th November, 2008 to 24 th May, 2009. A total 90 patients with lower ureteric ...

A. Alpha adrenergic blockers (alfuzosin, doxazosin, silodosin, tamsulosin, and terazosin) B. Hormonal manipulation (including finasteride, dutasteride, and dutasteride plus tamsulosin) C. Interstitial laser coagulation of the prostate (ILCP) D. Laser prostatectomy E. Laser based procedures including contact laser ablation of the prostate (CLAP), holmium laser procedures of the prostate (HoLAP, ...

Orally dissolving film (ODF) merupakan sediaan tipis yang cepat larut dalam mulut tanpa bantuan air minum, sehingga onset obat menjadi lebih dan meningkatkan kenyamanan pasien. Polimer hidroksi propil metil selulosa (HPMC) maltodekstrin jenis polimer banyak dikombinasikan ODF karena menghasilkan karakteristik baik. Tamsulosin HCl digunakan sebagai model memiliki dosis kecil, rasa pahit, kelarut...

of drugs through changes in clearance and distribution volume. In general, for drugs that show a high degree of hepatic or renal extraction (flow-limited drugs) after intravenous administration, alterations of plasma protein binding cause changes in the unbound plasma drug concentration at steady state but little change in the total concentration. Recently, these theoretical changes have been c...