The molecular chaperone HSP90 plays a crucial role in cancer cell growth and survival by stabilizing cancer-related proteins. A number of HSP90 inhibitors have been developed clinically for cancer therapy; however, potential off-target and/or HSP90related toxicities have proved problematic. The 4-(1Hpyrazolo[3,4-b]pyridine-1-yl)benzamide TAS-116 is a selective inhibitor of cytosolic HSP90a and ...

BACKGROUND Mass drug administration (MDA) for lymphatic filariasis (LF) programs has delivered more than 2 billion treatments of albendazole, in combination with either ivermectin or diethylcarbamazine, to communities co-endemic for soil-transmitted helminthiasis (STH), reducing the prevalence of both diseases. A transmission assessment survey (TAS) is recommended to determine if MDA for LF can...

background: thalassemic patients undergoing hematopoietic stem cell transplantation (hsct) are faced with cumulative high level of oxidative stress and depletion of critical antioxidants. administration of antioxidants, is promising towards minimizing oxidative damage in both thalassemic and hsct patients. method: this was a prospective cross-sectional observational study. patients as a part of...

We will study the magnetic correlations in the geometrically frustrated antiferromagnetic spinel CdCr2O4 using inelastic neutron scattering. In so doing, we will gain an an understanding of the principles of Triple-Axis Spectroscopy (TAS) and learn how to analyze the TAS data obtained to extract physical information about the system being studied.

PURPOSE To assess low-grade, systemic inflammation and antioxidant status as additional factors contributing to pathophysiology of essential arterial hypertension (HTN) and compare them with traditional risk factors, like abnormal lipids profile, considering their potential diagnostic usefulness. MATERIAL AND METHODS Serum high-sensitivity C-reactive protein (hs-CRP) concentrations and total ...

OBJECTIVE Alexithymia relates to difficulties recognizing and describing emotions. It has been linked to subjectively increased interoceptive awareness (IA) and to psychiatric illnesses such as major depressive disorder (MDD) and somatization. MDD in turn is characterized by aberrant emotion processing and IA on the subjective as well as on the neural level. However, a link between neural activ...

PURPOSE Generalized paroxysmal fast activity (GPFA), an EEG pattern with variable frequency and duration, is usually noted in symptomatic/cryptogenic generalized epilepsies. However, GPFA has also been reported in a few patients with genetic generalized epilepsy (GGE) who presented with typical absence seizures (TAS). Our aim was to report the results of long-term follow-up and genetic findings...

While peer-to-peer (P2P) file-sharing is a powerful and cost-effective content distribution model, most paid-for digital-content providers (CPs) rely on direct download to deliver their content. CPs such as Apple iTunes that command a large base of paying users are hesitant to use a P2P model that could easily degrade their user base into yet another free file-sharing community. We present TP2,...

Bacterial toxin-antitoxin (TAs) loci usually consist of two genes organized as an operon, where their products are bound together and inert under normal conditions. However, under stressful circumstances the antitoxin, which is more labile, will be degraded more rapidly, thereby unleashing its cognate toxin to act on the cell. This, in turn, causes cell stasis or cell death, depending on the ty...

NbSe$_3$ and monoclinic-TaS$_3$ ($m$-TaS$_3$) are quasi-1D metals containing three different types of chains undergoing two charge density wave (CDW) Peierls transitions at T$_{P_1}$ T$_{P_2}$. The nature these is discussed on the basis first-principles DFT calculation their electron-hole Lindhard response function. As a result stronger inter-chain interactions Fermi surface (FS) function consi...