mice. In particular, these types of studies have been performed using animals that have disrupted gustatory University of Denver Denver, Colorado 80208 innervation due to the lack of a particular neurotrophin, brain-derived neurotrophic factor (BDNF), or its principal receptor, trkB. BDNF is expressed in developing taste For the past century, studies of the development of taste papillae (Nosrat...

Many commonly prescribed chemotherapy drugs such as cyclophosphamide (CYP) have adverse side effects including disruptions in taste which can result in loss of appetite, malnutrition, poorer recovery and reduced quality of life. Previous studies in mice found evidence that CYP has a two-phase disturbance in taste behavior: a disturbance immediately following drug administration and a second whi...

Taste learning, and particularly conditioned taste aversion (CTA), is an adaptive learning involving complex brain mechanisms and molecular pathways. Taste learning and CTA are critical behaviors for survival, and the knowledge of the molecular bases involved in the acquisition, retention and extinction of CTA can help to understand the brain mechanisms of normal and altered taste learning. The...

The extractive constituents, which are known as taste active components of fisheries products in many research works have been reviewed..This review found glutamate, glycine, alanine, arginine, proline, valine, methionine, phenylalanine, tyrosine, inosine 5’-monophosphate (IMP), adenosine 5’monophosphate (AMP), guanosine 5’-monophosphate (GMP), trimethylamine, trimethylamine oxide (TMAO), glyci...

The sense of taste is responsible for the detection and ingestion of food to cover energetic requirements in health and disease. The change in taste perception might lead to malnutrition that is usually one of the frequent causes of morbidity and mortality in patients with cancer. In this review, we summarize the mechanisms of taste perception and how they are altered in cancer. We also address...

We report the case of a 16-year-old female patient with taste impairment of the soft palate. After receiving a skull fracture due to a traffic accident, she experienced the taste of bitter chocolate. CT showed the fracture around the right temporal bone. Electrogustometry showed that the decreased sensation of taste was restricted to the right soft palate. Shirmer test showed that lacrimal secr...

The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners. In contrast, human T1R1/T1R3 responds to the umami taste stimulus l-glutamate, and this response is enhanced by 5'-ribonucleotides, a hallm...

e-mail: [email protected] This article is based on the foreword for Symposia 15 (S15) of the 131st Annual Meeting of the Pharmaceutical Society of Japan. Fig. 1. Distribution of Nutrient Sensors in Gastrointestinal Organs Summary of current knowledge on the taste receptor gene expression is illustrated. T1Rs; T1R1/T1R3 (umami taste), T1R1/T1R3 (sweet taste); mGluRs; metabotrophic ...