نتایج جستجو برای: tau hyperphosphorylation

تعداد نتایج: 21929  

2014
E. Giraldo A. Lloret T. Fuchsberger J. Viña

Oxidative stress is a hallmark of Alzheimer's disease (AD). We propose that rather than causing damage because of the action of free radicals, oxidative stress deranges signaling pathways leading to tau hyperphosphorylation, a hallmark of the disease. Indeed, incubation of neurons in culture with 5 µM beta-amyloid peptide (Aβ) causes an activation of p38 MAPK (p38) that leads to tau hyperphosph...

Journal: :The Journal of biological chemistry 2010
G William Rebeck Hyang-Sook Hoe Charbel E-H Moussa

Alzheimer disease is characterized by extracellular beta-amyloid (Abeta) plaques and intracellular inclusions containing neurofibrillary tangles of phospho-Tau and intraneuronal Abeta associated with neuronal cell death. We generated a novel gene transfer animal model using lentiviral Abeta(1-42) that resulted in intracellular but not extracellular Abeta accumulations in the targeted rat primar...

Journal: :Neuron 2006
Laura E. Doglio Ritu Kanwar George R. Jackson Mar Perez Jesús Avila Colin Dingwall Carlos G. Dotti Mark E. Fortini Fabián Feiguin

Genetic analysis of familial Alzheimer's disease has revealed that mutations in the gamma-secretase enzyme presenilin promote toxic Abeta secretion; however, presenilin mutations might also influence tau hyperphosphorylation and neurodegeneration through gamma-secretase-independent mechanisms. To address this possibility and determine whether other components of the gamma-secretase complex poss...

Journal: :Journal of Alzheimer's disease : JAD 2013
Félix Hernández Esther García-García Jesús Avila

Inge Grundke-Iqbal and Khalid Iqbal found a connection between microtubule associated tau and Alzheimer's disease. They described that abnormally phosphorylated tau is a component of the paired helical filaments found in the disease. Afterwards they described that tau hyperphosphorylation prevents microtubule assembly. Now trying to complement the relationship between microtubules and tau phosp...

2012
Jianbin Zhang Tongjian Cai Fang Zhao Ting Yao Yaoming Chen Xinqin Liu Wenjing Luo Jingyuan Chen

Lead (Pb) is a well-known heavy metal in nature. Pb can cause pathophysiological changes in several organ systems including central nervous system. Especially, Pb can affect intelligence development and the ability of learning and memory of children. However, the toxic effects and mechanisms of Pb on learning and memory are still unclear. To clarify the mechanisms of Pb-induced neurotoxicity in...

Journal: :Journal of Alzheimer's disease : JAD 2011
Wei Wei Ying-Hua Liu Chang-E Zhang Qun Wang Zelan Wei Darrell D Mousseau Jian-Zhi Wang Qing Tian Gong-Ping Liu

Hyperhomocysteinemia is associated with an increased risk of Alzheimer's disease (AD). Our previous work has demonstrated that combined folate and vitamin B12 (vit-B12) supplementation prevents tau hyperphosphorylation and memory deficits induced by acute administration of homocysteine in young rats. Here, we further investigated whether folate/vit-B12 supplementation is also effective in aged ...

Journal: :Human molecular genetics 2012
Wendou Yu Jai Polepalli Dhananjay Wagh Jayakumar Rajadas Robert Malenka Bingwei Lu

Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia in the elderly. Accumulating evidence supports soluble amyloid-β (Aβ) oligomers as the leading candidate for the causative agent in AD and synapses as the primary site of Aβ oligomer action. However, the molecular and cellular mechanisms by which Aβ oligomers cause synaptic dysfunction and co...

2012
Akihiko Takashima

In Alzheimer's disease (AD), tau hyperphosphorylation and neurofibrillary tangle (NFT) formation are strongly associated with dementia, a characteristic and early feature of this disease. Glycogen synthase kinase 3β (GSK-3β) is a pivotal kinase in both the normal and pathological phosphorylation of tau. In the diseased state, hyperphosphorylated tau is deposited in NFTs, the formation of which,...

2007
Fei Dou Xingya Chang Da Ma

Hyperphosphorylation of tau leading to aggregated tau and tangle formation is a common pathological feature of tauopathies, including Alzheimer's disease. Abnormal phosphorylation of tau by kinases, in particular GSK3β, has been proposed as a pathogenic mechanism in these diseases. In this study we demonstrate that the heat shock protein 90 (Hsp90) maintains the stability and function of the GS...

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