The phenotypic features acquired subsequent to antigen-specific stimulation in vitro were evaluated by means of the kinetic expressions of CD69 and CD25 activation molecules on T lymphocytes and assayed by flow cytometry in response to PPD, Ag85B, and ferritin in PPD-positive healthy control individuals. In response to PHA, CD69 staining on both CD4+ and CD8+ T cells became initially marked aft...

BACKGROUND A better understanding of the quality of cellular immune responses directed against molecularly defined targets will guide the development of TB diagnostics and identification of molecularly defined, clinically relevant M.tb vaccine candidates. METHODS Recombinant proteins (n = 8) and peptide pools (n = 14) from M. tuberculosis (M.tb) targets were used to compare cellular immune re...

The Ag85 complex functions as the main secretory protein of Mycobacterium tuberculosis (M. tuberculosis) and BCG. This complex is composed of the proteins, Ag85A, Ag85B, and Ag85C, with Ag85A thought to play the largest role within the complex. However, the lack of commercially available monoclonal antibodies (mAbs) against Ag85A still hinders the biological and applicative research on this pro...

ةيوافمللا ةدغلا هلازإ لاجم يف انتربخ نايب ضرعتسن :فادهلأا .ركبلما يدثلا ناطرس تاضيرم ىدل ةسرالحا دلاخ كللما ىفشتسم يف ةيعجرلما ةساردلا هذه تيرجأُ :ةقيرطلا رياني ينب ام ةرتفلا للاخ ةيدوعسلا ةيبرعلا ةكلملما ،ضايرلا ،يعمالجا ناطرسب ةضيرم 120 ةساردلا تلمش .م2014 ربمسيد و م2005 عم ةسرالحا ةيوافمللا ةدغلا ةلازإ ةيلمعل نعضخ يتلالا و يدثلا ةصالخا تامولعلما عمج تم .ةدغلا هذهل ينلاا يحيرشتلا صحفلا و ةسرال...

ضارمأب ةباصلإا مدعو نسلا ةثادح نأ جئاتنلا ترهظأ :جئاتنلا ةيبلقلا ضارملأاو ،مدلا طغض عافتراو ،يركسلاك( ىرخأ ـب ةباصلإا نم مايأ ةعبس نوضغ يف جلاعلا يقّلتو )ةيئاعولا تاذ ةيعمس تاطيطخت دوجوو لدتعُحلما عمسلا نادقْفو ،ISSHL لضفأ ةقيرطب عمسلا ةداعتسا يف تمهاس ،ةدعاص تاءانحنا ةيقنلا ةمغنلا عمس سايق غلبو .ةيئاصحلإا ةيحانلا نم ريثكب ،طسوتلما يف لبيسيد 23.9 ± 67.8 رملأا لوأ يف )PTA( و لبيسيد 51.6±28.7 ىلإ ني...

طلتخملا رطيسملل ميمصت مدقي ثحبلا اذه نا LQR/H-infinity .ةدكؤملا ريغو تاريغتملا ةددعتم ةمظنلأل مت ةفلك ةلاد ىلع ادامتعا ةعجارلا ةيذغتلا ةلاح تباوثل ىلثملا ميقلا داجيا ضرغل يئيزجلا دشحلا ةيلثما ةقيرط مادختسا تاددحم نيب طيلخ نع ةرابع يه ةحرتقملا ةفلكلا ةلاد نا.ةحرتقم LQR و H-infinity حرتقملا رطيسملا نا. ريغتملا ةددعتم ةمظنلأا ضوعي نا ةياع ةءافكبو عيطتسي رطيسملا ةوق تابثا ضرغل .ةيدكؤملا مدع دوجوب ...

Tuberculosis (TB) is a serious public health problem, which ranks equal with human immunodeficiency virus infection as the top most killer globally among the infectious diseases [1]. Rapid and accurate diagnosis is crucial to control the disease so as to initiate an early antitubercular therapy. The GeneXpert MTB/RIF assay recently endorsed by the world health organization (WHO) has been a majo...