BACKGROUND Toxicity data from cancer trials are summarized into a single outcome, dose-limiting toxicity (DLT), which does not account for multiple lower grade toxic effects nor differentiates between toxicity types and gradations within DLT. METHODS Toxicity data were summarized into a toxicity burden score (TBS) using a weighted sum. The severity weights were estimated via regression using ...

Hyperbilirubinemia is a common problem during neonatal period especially in preterm neonates. Transcutaneous bilirubin measurement (TcB) by special devices had been documented as an effective tool for predicting neonatal jaundice in full term neonate, but for preterm infants the present evidences are controversial. We carried out a prospective study in Shariati Hospital NICU. 126 paired TcB/tot...

To maintain the accuracy of supervised learning models in the presence of evolving data streams, we provide temporally-biased sampling schemes that weight recent data most heavily, with inclusion probabilities for a given data item decaying exponentially over time. We then periodically retrain the models on the current sample. This approach speeds up the training process relative to training on...

Energy efficiency in industry is a key element decreasing costs and environmental impact. This especially applies to the battery production, due cost-sensitivity high potential A mandatory production step cell assembly dry rooms. The operation of rooms requires complex energy-intensive technical building services (TBS). Thus, questions regarding energy measures for TBS arise. paper suggests app...

Whether fat is beneficial or detrimental to bones is still controversial, which may be due to inequivalence of the fat mass. Our objective is to define the effect of body fat and its distribution on bone quality in healthy Chinese men. A total of 228 men, aged from 38 to 89 years, were recruited. BMD, trabecular bone score (TBS), and body fat distribution were measured by dual-energy X-ray abso...

Acute post-training exposures to weak intensity theta-burst stimulation (TBS) patterned complex magnetic fields attenuated the magnitude of conditioned fear learning for contextual stimuli. A similar learning impairment was evoked in a linear and dose-dependent manner by pre-conditioning injections of the polyamine agmatine. The present study examined the hypothesis that whole-body applications...

Seizure frequency is the only variable used for assessing therapeutic efficacy. Advances in quantitative analyses allow measurement of intensity, duration, spread, and time between seizures (TBS). These variables are used here to investigate the efficacy of brain electrical stimulation in humans with pharmacoresistant seizures. The results of a trial of contingent high-frequency electrical stim...

The energy consumption of air conditioning for a telecommunication base station (TBS) in China can be significantly decreased when an air to air thermosyphon heat exchanger is used for free cooling in low atmosphere temperature days. The model for the typical TBS in China was established and the air conditioning energy consumption was analyzed for the cities with climatic data in China. Taking ...