UNLABELLED Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent of disease. Here we evaluated preclinically 4 novel (99m)Tc-labeled small-molecule inhibitors of PSMA with the potential for clinical translation for molecular imaging of prostate cancer in humans. METHODS Fo...

UNLABELLED Early detection of heart disease is essential for the implementation of intervention strategies that reduce the risk of cardiovascular events. Radioimaging methods that have been explored for this purpose include (18)F-FDG, which measures sites of elevated metabolic activity; (99m)Tc-annexin A5, which reveals regions of enhanced apoptosis and thrombosis; and (99m)Tc-labeled anti-lect...

  Introduction: Ubiquicidin (UBI) 29-41 is a synthetic antimicrobial peptide that binds with the microbial cell membrane at the location of infection. This study was conducted to evaluate its probable efficacy as an infection-imaging agent with potential to differentiate bacterial infection from sterile inflammation in humans. Methods: Fifteen diabetic foot patients ...

Tc-99m-MIBI is an isonrtrile derivative used for evaluation of myocardial perfusion in recent years. In this preliminary report, 7 patients with coronary artery disease are evaluated with Tc-99m-MlBl stress planar and sped studies. Good correlation with coronary angiography is observed in these cases. In view of inherent technical problems present with thallium 201, Tc-99m-MIBi is a good ...

bilateral diffuse intense breast uptake was noted in a 40 year old female who was evaluated with tc-99m sestamibi (mibi) myocardial perfusion scan for possible ischemia. she was breast feeding her 1.5 year old child. the intense uptake in the breasts was superimposed on the apical and anteroapical regions of the myocardium and caused interpretation problem. we recommend considering tc-99m mibi ...

introduction: many radiotracers have been used for sentinel node mapping with acceptable results. the main difference between these radiotracers is the particle size. in the current study, we reported defective labeling of tc-99m antimony sulfide colloid which resulted in large particle size. methods: tc-99m-antimony sulfide colloid was used for axillary sentinel node mapping of 45 breast cance...

Correspondence to: Venkatesh L. Murthy, MD, PhD, 1338 Cardiovascular Center, 1500 E Medical Center Drive, SPC 5873, Ann Arbor, MI 48109-5873. E-mail [email protected] Venkatesh L. Murthy, MD, PhD Leslee J. Shaw, PhD Brahmajee K. Nallamothu, MD, MPH In the United States, single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) accounts for the overwhelming majorit...

The aim of this study was to evaluate the clinical efficacy of immunoscintigraphy with Tc-99m-labelled antigranulocyte antibody in combination with Tc-99m-methylene-diphosphonate (MDP) bone scanning in diabetic foot infection. The study group comprised 42 Type 2 diabetics with foot infection. Preand postprandial blood glucose level, HbA1c, urinary glucose, microalbuminuria, total cholesterol, L...

Introduction: This study was launched to evaluate the sensitivity and specificity of 99mTc-Ciprofloxacin to distinguish infection foci induced by staphylococcus aureus and inflammation lesions induced by carrageenan in the rat foot in comparison with 67Ga-Citrate scintigraphy. Methods: The labeling and quality control of 99mTc-Ciprofloxacin kits have been perfo...

Introduction: Differentiation between infection and sterile inflammation is one of the most difficult medical problems and is relevant in many clinical situations. Scintigraphy with radiolabeled antibiotics, еspecially labeled fluoroquinolones, is a promising tool for diagnosing bacterial inflammation. We have attempted to synthesize 99mTc-norfloxacin and studied its properties in ex...