BACKGROUND Low cobalamin concentrations are common, but their causes are often unknown. Transcobalamin I/haptocorrin (TC I/HC) deficiency, viewed as a rare cause, has not been examined systematically in patients with unexplained low serum cobalamin. METHODS Total TC I/HC was measured by RIA in three subgroups of 367, 160, and 38 patients with different categories of low cobalamin concentratio...

Potent and selective inhibition of neuronal nitric oxide synthase (nNOS) compared to endothelial NOS (eNOS) and inducible NOS (iNOS) may be useful to treat cerebral ischemia (stroke) and other neurodegenerative diseases. S-Methyl-L-thiocitrulline (Me-TC) and S-ethyl-L-thiocitrulline (Et-TC) inhibited the oxidation of L-arginine and the L-arginine-independent oxidation of NADPH by nNOS from huma...

Polymeric ultra-thin films (nanosheets) possess unique properties that make them suitable materials for various biomedical applications. In our previous study, we assessed the use of an antibiotic (tetracycline, TC)-loaded nanosheet (or "TC-nanosheet") for the treatment of gastrointestinal tissue defects. The nanosheet consisted of three functional layers: layer-by-layer nanosheet as a stable p...

BACKGROUND The mechanism and clinical relevance of increased core temperature (Tc) after surgery are poorly understood. Because fever is used as a diagnostic sign of infection, it is important to recognize what constitutes the normal postoperative thermoregulatory response. In the current study the authors tested the hypothesis that a regulated increase in Tc setpoint occurs after surgery. ME...

The variation of the phase-separation temperature (Tc) was studied in lenses during formation of cataracts induced by a subcutaneous injection of sodium selenite. In normal control animals, the Tc decreased monotonically with increasing age. Approximately 2 days after administration of the selenite the Tc decreased sharply to a minimum, and then at day 4 the Tc increased dramatically toward bod...

The long-term goal of this project is to improve the prediction of tropical cyclone (TC) genesis, structure and intensity changes through improved representation of 3-dimensional TC structure at the initial time. The accurate prediction of TC genesis, structure and intensity changes is critical to Navy missions and civilian activities in coastal areas. Significant gains have been made in the TC...

Phosphorylation of eIF2α controls translation initiation by restricting the levels of active eIF2-GTP/Met-tRNAi ternary complexes (TC). This modulates the expression of all eukaryotic mRNAs and contributes to the cellular integrated stress response. Key to controlling the activity of eIF2 are translation factors eIF2B and eIF5, thought to primarily function with eIF2-GDP and TC respectively. Us...

A c l a s s o f c o u n t a n d t h r e s h o l d m e c h a n i s m s , c o l l e c t i v e l y d u b b e d α c o u n t , a b l e t o d i s c r i m i n a t e b e t w e e n t r a n s i e n t f a u l t s a n d i n t e r m i t t e n t f a u l t s i n c o m p u t i n g s y s t e m s i s p r e s e n t e d . T r a n s i e n t f a u l t s d i s c r i m i n a t i o n h a s l o n g b e e n p u r s u e d...

Fate of light hadronic excitations above the critical temperature Tc of the QCD phase transition was first investigated 20 years ago.1,2 In Ref. 1 whose title is “Fluctuation effects in hot quark matter: precursors of chiral transition at finite temperature”, the hadrinic modes above Tc were discussed in connection with the critical fluctuation associated with chiral symmetry restoration: The a...