A physiologically based pharmacokinetic (PB-PK) model was developed to describe trichloroethylene (TCE) kinetics in the lactating rat and nursing pup. The lactating dam was exposed to TCE either by inhalation or by ingestion in drinking water. The nursing pup's exposure to TCE was by ingestion of maternal milk containing TCE. The kinetics of trichloroacetic acid (TCA), a metabolite of TCE, were...

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials. Herein, we describe 11 genetic knockout (KO) lines that delete six of the eight mitochondrial tricarboxylic acid (TCA) cycle enzymes. Although all TCA KOs grew normally in asexual blood st...

BACKGROUND Despite the popularity of acupuncture, evidence of its efficacy for reducing pain remains equivocal. OBJECTIVE To assess the efficacy and safety of traditional Chinese acupuncture (TCA) compared with sham acupuncture (needling at defined nonacupuncture points) and conservative therapy in patients with chronic pain due to osteoarthritis of the knee. DESIGN Randomized, controlled t...

An attempt has been made to partially characterize the substance responsible for the rhythmic incorporation of 35S (inorganic sulfate) in the course of the cell cycle in early Limnaea embryos. This trichloroacetic acid (TCA) insoluble substance is partly pronase sensitive, and dissociable into two fractions after treatment with NaCl. One of these remains TCA-insoluble while the other is TCA sol...

We report a case that involves the use of intravenous lipid emulsion as an antidote for a drug overdose involving a 20-month-old girl who had ingested a potentially lethal amount of the tricyclic antidepressant (TCA) dothiepin. The patient's condition continued to deteriorate despite implementation of standard pediatric treatment recommendations for TCA toxicity. Administration of intravenous l...

The trigeminocerebellar artery (TCA) is a branch of the basilar artery that may have an intraneural course and may cause trigeminal neuralgia. We report a case of trigeminal neuralgia with right vertebral artery aneurysm caused by an intraneural TCA that compressed the trigeminal nerve in multiple places. We performed proximal trapping for the fusiform aneurysm with extra-intracranial bypass to...

Gastric instillation of 125I-labelled protein in mice leads to rapid appearance of blood radioactivity which is precipitable with 10% trichloroacetic acid (TCA). The same occurs when Na125I is given by mouth. Parenteral administration of non-radioactive NaI before feeding Na125I or 125I-labelled protein inhibits the appearance of TCA-precipitable radioactivity in the blood. The results presente...

To evaluate the effectiveness of 50% Tricolored acetic acid (TCA) instillation in uterine cavity for treatment Abnormal bleeding (AUB). In this study, 40 patients with complaints menstrual bleeding, without any organic cause after ruling out malignancy were taken into consideration. After individually calculating volume TCA, it was instilled chemically ablation endometrium. a follow-up 3 months...

The first is representation stability: a generalization of homological stability in the presence of group actions which was introduced by Church and Farb. For symmetric group actions, this is formalized in the notion of FI-modules, introduced by Church, Ellenberg, and Farb. FI-modules turn out to be modules over a twisted commutative algebra (the free tca generated by 1 element of degree 1). Th...